里尔统与依那普利逆转早期肾损害的临床观察  

The Clinical Research of Creatine Phosphate Sodium and Enalapril Towards the Reversal of Early Renal Injure

作　　者：王瑛[1] 陈玉丽 坂本真吾 林阳 周荣英 姜晓庆 永井阳子 朴鑫 崔玉娟 王薇 迟小小 

机构地区：[1]长春市中心医院,辽宁长春130000 [2]大连维特奥国际医院

出　　处：《中外医学研究》2012年第25期5-6,共2页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:观察里尔统与依那普利联合应用逆转早期肾损害的临床疗效。方法:66例肾脏早期损害患者随机分为治疗组和对照组,在治疗原发疾病的基础上,均口服依那普利10mg,2次/d,治疗组加用里尔统静脉点滴2.0g,1次/d。两组均在治疗前、治疗后两周测晨尿微量白蛋白(MAU)、N-乙酰-β-D氨基葡萄糖苷酶(NAG)及相关理化检查。结果:两组治疗前与治疗后比较,MAU和NAG均有降低,但治疗组MAU和NAG的改善较对照组明显,差异有统计学意义(P<0.05)。结论:在常规治疗原发疾病的基础上,里尔统对肾脏早期损害有逆转作用,与依那普利联合应用治疗效果优于单一使用依那普利。Objective ：To observe the effect of combination use of creatine phosphate sodium and enalapril towards the reversal of early renal injure. Methods ：66 cases of early renal injury patients were randomly divided into treatment group and control group.Both were given enalapril 10 mg orally twice a day on the basis of treating the primary diseases.The treatment group was also given creatine phosphate sodium 2.0 g IV daily.Urine micro albumin （MAU）, N-acetyl-13 -D-glucosaminidase （NAG） and few relevant laboratory test of the morning urine of both groups were checked before and after two weeks treatment regime.Results ：After the treatment, MAU and NAG in both groups reduced, but the change was more evident and statistically significant in treatment group. Conclusion ：Based on the treatment of the primary diseases, creatine phosphate sodium exhibits a reversal effect on the early renal injury.With the combination of enalapril in treatment, creatine phosphate sodium is superior to enalapril alone.

关 键 词：里尔统 依那普利 早期肾损害 逆转治疗 

分 类 号：R692[医药卫生—泌尿科学]