Synthesis and Crystal Structure of 1,7,8,9-Tetrachloro-4-benzyl-10,10-dimethoxy-4-azatricyclo(5,2,1,0^(2,6))dec-8-ene-3,5-dione  

作　　者：单文治 顾苏俊 刘河 

机构地区：[1]Department of Clinical Pharmacology,Chinese PLA General Hospital [2]Beijing Chao-Yang Hospital Affiliated with Beijing Capital Medical University

出　　处：《Chinese Journal of Structural Chemistry》2012年第10期1524-1527,共4页结构化学（英文）

基　　金：supported by the NNSFC(No.81072530 and 30772653)

摘　　要：The crystal structure of 1,7,8,9-tetrachloro-4-benzyl-10,10-dimethoxy-4-azatricyclo- （5,2,1,0^2,6）dec-8-ene-3,5-dione （C18H15Cl4NO4, Mr = 451. 11） has been determined by single-crystal X-ray diffraction analysis. The crystal belongs to the monoclinic system, space group P21/c with a = 18.6488（2）, b = 13.06430（10）, c = 16.1086（2）A, β = 92.9870（10）°, V = 3919.26（7） A3, Z = 8, Dc = 1.529 g/cm3,μ = 5.711 mm-1, F（000） = 1840, the final R = 0.0599 and wR = 0.1664 for 5645 observed reflections. The title compound is composed of a polycyclic fused pyrrolidine ring system. Three symmetric fused five-membered-ring structures were formed by the Diels-Alder reaction between N-benzylmaleimide and 5,5-dimethoxy-1,2,3,4-tetrachlorocydopentadiene.The crystal structure of 1,7,8,9-tetrachloro-4-benzyl-10,10-dimethoxy-4-azatricyclo- （5,2,1,0^2,6）dec-8-ene-3,5-dione （C18H15Cl4NO4, Mr = 451. 11） has been determined by single-crystal X-ray diffraction analysis. The crystal belongs to the monoclinic system, space group P21/c with a = 18.6488（2）, b = 13.06430（10）, c = 16.1086（2）A, β = 92.9870（10）°, V = 3919.26（7） A3, Z = 8, Dc = 1.529 g/cm3,μ = 5.711 mm-1, F（000） = 1840, the final R = 0.0599 and wR = 0.1664 for 5645 observed reflections. The title compound is composed of a polycyclic fused pyrrolidine ring system. Three symmetric fused five-membered-ring structures were formed by the Diels-Alder reaction between N-benzylmaleimide and 5,5-dimethoxy-1,2,3,4-tetrachlorocydopentadiene.

关 键 词：polycyclic fused pyrrolidine ring Diels-Alder reaction crystal structure 

分 类 号：O627[理学—有机化学]