ApoM基因启动子区T-788C多态性与急性冠脉综合征的关系  

Polymorphisms in the ApoM gene confer the susceptibility to acute coronary syndrome

作　　者：张效林[1] 刘腾飞[1] 蔡文芝[1] 闫承慧[1] 梁振洋[1] 孙莹[1] 冯雪瑶[1] 韩雅玲[1] 

机构地区：[1]沈阳军区总医院,沈阳110016

出　　处：《山东医药》2012年第29期1-3,共3页Shandong Medical Journal

基　　金：国家自然科学基金青年科学基金项目(81100135);军队临床高新技术重大项目(2010GXJS001)

摘　　要：目的探讨ApoM基因启动子区T-788C多态性与急性冠脉综合征(ACS)的关系。方法采用聚合酶链反应—限制性片段长度多态性技术结合琼脂糖凝胶电泳和基因测序等对675例ACS患者(ACS组)和636例正常健康体检者(对照组)的ApoM基因启动子区T-788C基因型和等位基因频率进行检测。结果 ApoM基因启动子区T-788C多态性在ACS组和对照组的分布频率符合Hardy-Weinberg平衡定律。ApoM基因启动子区T-778C C等位基因及CC基因型ACS组显著高于对照组(P均<0.01)。Logistic回归分析显示,在校正冠状动脉疾病易感因素后,ApoM基因启动子区T-788C C等位基因是ACS发病的独立危险因素(OR=2.14,95%CI为1.08～2.86,P<0.01)。结论 ApoM基因启动子区T-778C多态性与ACS发病存在相关性,其中C等位基因是其独立危险因素。Objective To investigate the possible association between the ApoM gene T-788C polymorphism and acute coronary syndrome （ACS）. Methods A casecontrol study was conducted in 675 patients with ACS and 636 control who had normal coronary angiograms. Polymorphic genotypes were determined by means of polymerase chain reaction and restric tion fragment length polymorphism, sequencing analysis. Results The genotype frequencies in ApoM T-788C polymor phism conformed well to the Hardy-Weinberg equilibrium in both case and control group. Single marker analysis for ApoM T-778C indicated that ACS patients had increased frequency of C allele in comparison with the controls （ P 〈 0.01 ）. Logis tic regression analysis with adjustments for other risk factors revealed that the ApoM T-788C allele carriers significantly in creased risk of ACS compared with the noncarriers. Conclusions The ApoM T-778C polymorphism confers the risk in the development of ACS among Han Chinese.

关 键 词：冠状动脉疾病 基因 多态性 单核苷酸 

分 类 号：R543.3[医药卫生—心血管疾病]