宫颈癌抑癌基因甲基化的研究进展  

Research Process of Cervical Cancer Anti-oncogenes Methylation

作　　者：巫剑红[1] 代荫梅[1] 

机构地区：[1]首都医科大学附属北京妇产医院妇科微创中心,北京100026

出　　处：《医学综述》2012年第19期3187-3190,共4页Medical Recapitulate

基　　金：北京市教委科技计划面上项目(KM201010025022)

摘　　要：宫颈癌是最常见的妇科恶性肿瘤之一,严重威胁女性健康。DNA甲基化是肿瘤发生的早期事件,因此通过检测基因的甲基化异常来进行肿瘤的早期诊断具有重要的临床意义。近年来研究表明,DNA甲基化与宫颈癌及癌前病变的发生、发展密切相关。现重点阐述宫颈癌抑癌基因的甲基化及其临床意义,并总结目前宫颈癌甲基化基因的研究方法。Cervical cancer is one of the most common female cancers, severely threatening female health. DNA methylation is an early event in carcinogenesis and is often present in a variety of cancers, so it has great clinical value to detect methylated genes for early diagnosis of cancers. In recent years, studies have shown that DNA methylation is closely associated with the genesis and development of cervical cancer and precancerous lesions. The review is to illustrate anti-oneogenes methylation of cervical cancer and the clinical value, and to summarize the DNA methylation analysis methods.

关 键 词：宫颈癌 DNA甲基化 抑癌基因 研究方法 

分 类 号：R711.74[医药卫生—妇产科学]