子宫颈鳞癌中PTEN、C-myc、P27的表达及其临床意义  

Expression and clinical significance of PTEN,C-myc and p27 in squamous cell carcinoma of the cervix

作　　者：郭艳萍[1] 杨广英[1] 王建君[1] 孙丽[1] 李军[1] 

机构地区：[1]郑州人民医院病理科,河南郑州450002

出　　处：《河南医学研究》2012年第3期295-298,共4页Henan Medical Research

基　　金：郑州市卫生局科技基金资助项目(2010-45)

摘　　要：目的:探讨PTEN、C-myc、P27在正常宫颈黏膜上皮、宫颈上皮内瘤变(CINⅡ-Ⅲ)及宫颈鳞癌组织中的表达及意义。方法:采用免疫组化SP法检测40例正常宫颈黏膜上皮、40例宫颈上皮内瘤样病变(CINⅡ-Ⅲ)及40例宫颈鳞癌组织中PTEN、C-myc及P27的表达。结果:PTEN、C-myc、P27的阳性表达率在正常宫颈黏膜上皮、宫颈上皮内瘤样病变(CINⅡ-Ⅲ)及宫颈鳞癌中分别为87.50%、50.00%、32.10%,25.00%、52.50%、82.50%和78.90%、40.30%、12.50%;PTEN蛋白和P27蛋白的失表达和C-myc蛋白的高表达,与宫颈鳞癌的组织学分级、浸润深度及淋巴结转移有关(P<0.05);宫颈鳞癌组织中PTEN及P27的表达具有相关性(P<0.01)。结论:PTEN、P27蛋白低表达和C-myc蛋白的高表达与宫颈癌的发生、发展、浸润及转移有关,联合检测PTEN、C-myc及P27的表达可以在一定程度上预测宫颈癌患者预后并指导治疗。Objective： To study the expression and clinical significance of PTEN,C-myc and P27 in squamous cell carcinoma of the cervix.Methods： To detect the expression of PTEN,C-myc and P27 in 40 cases of chronic cervicitis,40cases of CIN and 40cases of SCC by immunohistochemical techniques.Results： The positive expression rates of PTEN,C-myc and P27 in chronic cervicitis,CIN and SCC were 87.50%,50.00%,32.10%,25.00%,52.50%,82.50%,78.90%,40.30%,12.50%,respectively.The low expression of PTEN and P27 was correlated with invasion and lymph node metastasis.The high expression of C-myc was correlated with invasion and lymph node metastasis.Conclusion： The low expression of PTEN and P27,and high expression of C-myc were correlated with development,invasion and metastasis of human SCC.The PTEN expression was negative correlation with P27 expression in SCC,and they can be signals for detecting the invasion and metastasis of human SCC.

关 键 词：子宫颈鳞癌 PTEN C-MYC蛋白 P27 免疫组化 浸润转移 

分 类 号：R446.8[医药卫生—诊断学]