活性氧双向生物学效应和机制  

Bidirectional Biological Effects and Mechanisms of Reactive Oxygen Species

作　　者：戴甲培[1,2] 石悦[1,3] 

机构地区：[1]中南民族大学武汉神经科学与神经工程研究所,武汉430074 [2]中南民族大学药学院,武汉430074 [3]中南民族大学生命科学学院,武汉430074

出　　处：《中南民族大学学报（自然科学版）》2012年第3期43-51,共9页Journal of South-Central University for Nationalities：Natural Science Edition

基　　金：国家自然科学基金面上项目(31070961);中南民族大学重点科研机构基金(XJS9001)

摘　　要：指出了活性氧(ROS)是普遍存在于有氧代谢中的产物,其化学性质极为活跃,有关ROS对人体的危害已逐渐得到公认.然而,越来越多的研究提示,一直被认为是人类疾病元凶的ROS对机体和细胞也有有益的一面.综述了ROS的研究进展,揭示了ROS通过调节离子通道、受体、酶以及转录因子的活性和改变细胞氧化还原状态,进而参与细胞的正常生理过程(细胞的增殖、分化和凋亡),从而讨论了ROS的双向生物学效应和机制.Reactive oxygen species （ROS） are the common products of aerobic metabolism, having extremely high chemical activity. The deleterious effects of ROS on human body have been well known. However there are more and more studies suggesting that ROS, considered as the major cause for human diseases, also has the beneficial effects. This paper has summarized the research progress to reveal that R0S involves in a variety of normal physiological activities such as cellular proliferation, differentiation and apoptosis by mediating the activities of ion channels, receptors, enzymes and transcription factors and regulating the cellular redox buffering capacity, and the bidirectional biological effects and mechanisms of ROS are discussed.

关 键 词：活性氧 氧自由基 脂质过氧化 信号转导 双向生物学效应 

分 类 号：Q2[生物学—细胞生物学]