解毒通瘀复肾汤对慢性肾脏病1-3期患者尿CTGF水平的影响  

Effect of Antidote Tongyu Fushen Decoction on the level of urine CTGF of the phase Ⅰ-Ⅲ chronic nephritis patients

作　　者：蓝健姿[1] 严晓华[1] 阮诗玮[2] 金一顺[1] 张雪梅[1] 

机构地区：[1]福建医科大学省立临床医院中医科,福州350001 [2]福建省人民医院肾内科,福州350005

出　　处：《中华中医药杂志》2012年第10期2548-2551,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：福建省卫生厅中医药科研重点课题(No.WZZS0602)~~

摘　　要：目的:观察解毒通瘀复肾汤配合西药治疗慢性肾脏病1-3期患者的疗效,探讨延缓慢性肾炎纤维化的有效方法。方法:90例患者随机分为两组,治疗组用解毒通瘀复肾汤加减配合西药,对照组用洛汀新或代文。结果:两组在总体疗效上无显著性差异,但治疗组在中医证候积分改善上明显优于西药对照组(P<0.05)。结论:中西医结合治疗和单纯西药治疗均能够有效减低尿蛋白和尿结缔组织生长因子(CTGF)的水平,缓解慢性肾炎纤维化的进程,但是中西医结合治疗在改善中医症候上相对西药治疗更加有优势。Objective： To observe the curative effect of Antidote Tongyu Fushen Decoction and Western medicine on chronic nephritis phase Ⅰ-Ⅲ patients, then explore the effective method to postpone chronic nephritis fibrosis. Methods： Patients were randomly divided into two group, the treatment group were taken Antidote Tongyu Fushen Decoction and Western medicinon（exclude Lotensin or Valsartan capsule）, and the control group received Lotensin or Valsartan capsule. Results： There is not much difference between the two groups＇ curative effect, but the improvement of the treatment group＇s TCM symptoms is much better than the control group＇s（P〈0.05）. Conclusion： The curative effect of combination of TCM and Western medicine is the same as that of pure Western medicine on the effectively reduction of the levels of urine protein and urine CTGF. But on the fact of the improvement of the TCM symptoms, the curative effect of combination of TCM and Western medicine is superior to that of pure Western medicine.

关 键 词：解毒通瘀复肾汤 慢性肾脏病1-3期 尿结缔组织生长因子 纤维化 

分 类 号：R692[医药卫生—泌尿科学]