治疗药物监测实践及结果分析  

Practice and Result Analysis of Therapeutic Drug Monitoring

作　　者：林宇涵[1] 许双临[1] 陈子春[1] 

机构地区：[1]福建医科大学教学医院宁德市医院,宁德352100

出　　处：《中国中医药现代远程教育》2012年第18期35-36,共2页Chinese Medicine Modern Distance Education of China

摘　　要：目的分析治疗药物监测结果,评价其临床效果和意义。方法采用HPLC法测定5种药物的血药浓度,对监测结果进行分析、统计。结果治疗药物监测结果在有效治疗窗内的仅占56.7%。监测值在低、中、高血药浓度范围内出现临床症状、症状控制、中毒症状的比例分别为90.5%、94.1%、100%。结论治疗药物监测对临床个体化给药具有重要意义。Objective To analyze and evaluate the results of therapeutic drug nonitonng （TDM） data. Methods The blood concentrations of 5 drugs were measured by HPLC, analysis and statistics of TDM data were carried out. Results Among all the TDM concentration, only 56.7% was within the therapeutic window. The monitoring value at low, medium and high blood drug level respectively within the scope of clinical symptoms appear, symptom under control, toxic symptom ratio was 90.5%, 94.1% and 100%. Conelusion Therapeutic drug monitoring is significant for individual administration in clinical.

关 键 词：治疗药物监测 血药浓度 

分 类 号：R96[医药卫生—药理学]