一种空气复方消毒液相关性能的研究  

STUDY ON PROPERTIES OF A COMPOUND DISINFECTANT SOLUTION IN AIR DISINFECTION

作　　者：宋江南[1] 陈贵秋[1] 庄世锋[1] 朱应凯[1] 李世康[1] 易亮[1] 聂焱[1] 

机构地区：[1]湖南省疾病预防控制中心,长沙410005

出　　处：《中国消毒学杂志》2012年第8期670-673,共4页Chinese Journal of Disinfection

摘　　要：目的研究一种以六亚甲基四胺和苯扎溴铵为杀菌成分的空气消毒液杀菌效果及其他消毒相关性能。方法采用模拟现场和现场空气消毒试验和动物试验及理化分析方法,对该消毒液性能进行了试验观察。结果以总活性物浓度为9 180 mg/L的该空气消毒液在20 m3的气雾室内按20 ml/m3用量,用气溶胶喷雾器喷雾消毒作用15 min,对气雾室空气中人工染白色葡萄球菌的平均消除率均达99.9%以上。按相同用量用气溶胶喷雾器喷雾消毒作用30 min,对现场普通房间空气中自然菌的平均消除率为95.28%。该空气消毒液对小鼠急性经口毒性试验LD50值>5 000 mg/kg(体重),急性吸入毒性LC50值>10 000 mg/m3·2 h。均属无毒级;对小鼠骨髓嗜多染红细胞结果阴性。该消毒液原液对家兔完整皮肤和眼黏膜刺激试验评分为0。结论该复方季铵盐空气消毒液对空气中细菌繁殖体具有较好的杀菌效果,属于无毒级物质,对完整皮肤和眼黏膜无刺激性。Objective To study the germicidal efficacy and other disinfection related properties of an air disinfectant with the quaternary ammonium salt as the main sterilization ingredient.Methods The air disinfection test on the simulating scene and on the scene,the physicochemical analysis method and animal experiments were used to observe the disinfection performance of this disinfectant.Results In a fog room of 20 m^3,the killing rate of Staphylococcus albus aritificially contaminated in air exposed to the air disinfectant containing the gross active matter 9 180 mg/L sprayed with the dosage of 20 ml/m^3 for 15 min was99.90%.In the normal room the killing rate of the indoor air natural bacteria exposed to the same concentration and dosage of the air disinfectant spray for 30 min was 95.28%.The LD50 of the air disinfectant in mice acute oral toxicity was 5 000 mg/kg·bw and the mouse acute inhaled toxicity LC50 was 10 000 mg/m 3·2 h,which showed this disinfectant belonged to non-toxic.Result of mouse bone marrow polychromatic erythrocyte micronucleus test was negative.The rabbit intact skin and eye mucous membrane irritation test scores were 0.Conclusion The compound quaternary ammonium salt air disinfectant has good germicidal efficacy on bacterium vegetative in the air and belongs to nontoxic class.It has no irritant effect on intact skin and eye mucous membrane of rabbit.

关 键 词：季铵盐 空气消毒液 杀菌效果 毒性 

分 类 号：R187.1[医药卫生—流行病学]