左旋卡尼汀改善慢性心力衰竭患者心功能及血浆脑钠肽的临床分析  

clinical analysis of L-carnitine improving heart function and plasma BNP in patients with chronic heart failure

作　　者：童立鹤 

机构地区：[1]安徽省肥西县人民医院,安徽肥西231200

出　　处：《安徽医药》2012年第11期1681-1683,共3页Anhui Medical and Pharmaceutical Journal

摘　　要：目的观察左旋卡尼汀(L-carnitine,L-CN)治疗慢性心力衰竭(CHF)患者的临床疗效。方法将56例慢性心力衰竭患者随机分为对照组28例和治疗组28例,对照组给予地高辛、利尿剂、血管紧张素转换酶抑制剂或血管紧张素Ⅱ受体拮抗剂及β受体阻滞剂治疗,治疗组在此基础上加用国产左旋卡尼汀3 g静脉滴注,每天1次,连续用药14 d,观察治疗前及治疗后患者的心功能及血浆BNP变化。结果治疗组的疗效优于对照组(P<0.05);治疗组治疗后心排血量(SV)、心输出量(CO)、心脏指数(VI)、左室射血分数(LVEF)、心功能分级(NYHA)与血浆脑钠肽(BNP)水平都明显改善,差异均有统计学意义(P<0.05),与对照组比较,差异也均有统计学意义(P<0.05),治疗组改善优于对照组。结论左旋卡尼汀能改善慢性心力衰竭患者的心功能,提高患者的临床疗效,可以作为心力衰竭的辅助治疗。Objective To observe the effect of Lcarnitine （LCN） in the treatment of congestive heart failure （CHF）. Methods 56 pa tients with chronic heart failure were divided into control group 28 patients and therapy group 28 patients. The control group patients were given basic treatment with digoxin, diuretics, angiotensin converting enzyme inhibitor （ACEI）or angiotensin Ⅱ receptor blocker （ARB）, and βblocker;the therapy group were given Lcamitine 3 g · d1 for 14 days in addition to the basic treatment. Heart function and BNP level in chronic heart failure patients was observed before and after Lcamitine treatment. Results The efficiency of the treatment group was better than control group （ P 〈 0.05 ） ; After treatment Heart discharge blood （SV） , cardiac output （ CO）, heart index （ VI）, left ventricular ejection fraction （LVEF） , and cardiac function classification （NYHA） and plasma BNP （BNP） levels were obviously im proved for therapy group（ P 〈 0.05 ） ; Compared with control group, the differences are statistically significant （ P 〈 0.05 ）, the improve ment of the treatment group Is superior to control group. Conclusion Lcarnitine can be used as adjuvant therapy to improve the heart function in chronic heart failure patients.

关 键 词：左旋卡尼汀 心力衰竭 心功能 脑钠肽 

分 类 号：R541.6[医药卫生—心血管疾病]