慢性光化性皮炎42例临床分析  

Clinical Analysis of 42 Cases with Chronic Actinic Dermatitis

作　　者：贾祎鹏[1] 谢方明[1] 陈岳[1] 成先桂[1] 贺镜宇[1] 韦燕兵[1] 

机构地区：[1]中国人民解放军第303医院,南宁530021

出　　处：《中国中西医结合皮肤性病学杂志》2012年第4期230-232,共3页Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine

摘　　要：目的探讨慢性光化性皮炎的诱发因素,临床特征,病理,光敏特征,治疗情况和复发情况。方法回顾性分析42例慢性光化性皮炎患者治疗前及治疗出院后3个月内的临床资料。结果 42例患者中,皮疹分布于暴露部位皮肤,为浸润性增厚的苔藓样丘疹和斑块等改变,有光敏感,男女比率为20∶1,50~70岁年龄段的患者占81%,从事农业劳动者占78.6%,病程长于5年者占50%,光学试验中78.9%的患者中波紫外线最小红斑量值（ultraviolet B-minimal erythema dose,UVB-MED）低于正常,为8~20 mJ/cm2之间;治疗上严格避光,给予大剂量糖皮质激素可迅速控制病情,但3个月内复发迅速,使用复方甘草酸苷注射液、沙利度胺、羟氯喹的方案起效较慢,但3个月内效果持久。结论慢性光化性皮炎的发生与日光照射密切相关,避光是治疗关键,应减少糖皮质激素在治疗中的应用。Objective To study the precipitating factors,clinical features,pathology,photosensitive features,treatment and recurrence features in patients with chronic actinic dermatitis.Methods Clinical data of 42 cases with chronic actinic dermatitis were analyzed retrospectively.Results Lesions were distributed on the exposed skin.They were made of invasive thickening lichenoid papules,plaques and other changes.They were photosensitive.In the 42 cases,the ratio of male and female was 20∶1.81% of the patients were 50 to 70 years old.And 78.6% of the patients were farmers.The course of more than five years accounted for 50%.78.9% of the patients was found lower ultraviolet B(UVB) minimal erythema dose(MED),ranging from 8 mJ/cm2 to 20 mJ/cm2.With ultraviolet avoidance,the symptoms could be reduced rapidly by takeing high dose corticosteroids.But the recurrence was rapid in three months.The symptom of the patients that treated with compound glycyrrhizin injection,Thalidomide and Hydroxy chloroquine reduced slowly,and the effect could be lasted for three months.Conclusion The occurrence of chronic actinic dermatitis was closely related to photosensitive.Ultraviolet avoidance was the key point,and the use of corticosteroids should be reduced in treatment.

关 键 词：慢性光化性皮炎 糖皮质激素 复方苷草酸苷 

分 类 号：R758.14[医药卫生—皮肤病学与性病学]