血液透析联合血液灌流对维持性血液透析患者中分子物质清除的研究  

Observation and analysis of medium molecule substance clearance among patients undergoing maintenance hemodialysis with hemodialysis plus hemoperfusion

作　　者：刘蔓莉[1,2] 杨斌[1,2] 全大勇[1,2] 范妙仪[1,2] 皮婧静[1,2] 龚蓉[1,2] 程弓[1,2] 

机构地区：[1]重庆医科大学附属第二临床学院 [2]成都市第三人民医院肾脏科,四川成都610031

出　　处：《中国医药科学》2012年第19期46-47,共2页China Medicine And Pharmacy

摘　　要：目的探讨血液透析联合血液灌流对维持性血液透析患者iPTH、β2-MG及Hcy清除的效果。方法选取在笔者所在医院行维持性血液透析患者15例,采用自身对照研究,HD组:单纯血液透析治疗组;HP+HD组:血液灌流串联血液透析治疗组。比较两组治疗12周前后iPTH、β2-MG、Hcy水平变化。结果 HP+HD组在治疗12周后,iPTH、β2-MG、Hcy水平明显降低,差异有统计学意义(P<0.05);HD组治疗12周后,iPTH、β2-MG、Hcy水平前后比较,差异无统计学意义(P>0.05)。结论 HD+HP治疗可以有效清除iPTH、β2-MG和Hcy。Objective To investigate the effect of clearance of iPTH, 13 2-MG and Hey among patients undergoing maintenance hemodialysis with hemodialysis plus hemoperfusion （HD＋HP）. Methods We randomly assigned 15 patients undergoing maintenance hemodialysis in our hospital into HD,HD＋HP group and compared the level of iPTH, 13 2-MG and Hey in both group before and after 12 weeks of treatment. Results The level of iPTH, 13 2-MG and Hey decreased significantly after 12 weeks of treatment in HD＋HP group（P 〈 0.05）while the level of iPTH, [3 2-MG and Hey were not significantly changed after 12 weeks of treatment （P 〉 0.05）. Conclusion HD＋HP can effectively clear iPTH, 13 2-MG and Hey.

关 键 词：血液透析 血液灌流 全段甲状旁腺激素 Β2-微球蛋白 同型半胱氨酸 

分 类 号：R459.5[医药卫生—治疗学]