^(131)碘治疗Grave病患者血清中白细胞介素-2、白细胞介素-12p40蛋白水平改变及临床意义  

The Change of Serum Interleukin-2 and Interleukin-12p40 in Patients with Grave's Disease after Treatment with ^(131)I and Its Significance

作　　者：钟莉 陈秋[2] 杨廷强[3] 

机构地区：[1]龙泉驿区第一人民医院内分泌代谢科,成都610100 [2]成都中医药大学内分泌科 [3]新津县人民医院内分泌科

出　　处：《华西医学》2012年第9期1335-1337,共3页West China Medical Journal

摘　　要：目的探讨Grave病患者采用131I治疗前后血清中白细胞介素-2(IL-2)及白细胞介素-12 p40(IL-12p40)含量的改变及细胞因子在该疾病中的作用与意义。方法采用酶联免疫吸附试验双抗夹心法、放射免疫法,对2009年10月-2011年12月收治的28例Grave病患者(治疗组)经131I治疗前后血清中IL-2和IL-12p40含量进行自身对比及与健康志愿者(对照组)对比;同时对治疗组患者治疗前、后的血清游离三碘甲腺原氨酸(FT3)、血清游离甲状腺素(FT4)、促甲状腺激素(TSH)水平与对照组进行对比。结果治疗后患者血清中IL-2和IL-12p40的水平为(19.54±11.17)、(615.88±349.32)ng/mL,明显高于治疗前(P<0.05),且与对照组比较差异无统计学意义(P>0.05);患者治疗前后血清中IL-2和IL-12p40水平与FT3、FT4水平有显著相关性。结论血清IL-2和IL-12p40可能共同参与Grave病的发病过程,并且这两种因子的水平与FT3、FT4水平呈负相关性。Objective To investigate the effects and significance of serum interleukin-2（IL-2） and interleukin-12p40（IL-12p40） changes before and after treatment with 131I in patients with Grave＇s disease.Methods The levels of IL-2 and IL-12p40 in the serum of 28 patients with Grave＇s disease who were treated between October 2009 and December 2011 before and after treated by 131I were measured and compared by radioimmunoassay.In addition,those levels and levels of free triiodothyronine（FT3）,free thyroxine（FT4） and thyroid stimulating hormone（TSH） in the serum of the patients were also compared with healthy volunteers.Results The levels of IL-2 and IL-12p40 in patients with Grave＇s disease were significantly lower than those in healthy volunteers and post-treatment patients [IL-2 level,（19.54 ± 11.17） ng/mL;IL-12p40 level,（615.88 ± 349.32） ng/mL] by 131I（P〈0.05）,but those two levels were not significantly different between the latter two groups of subjects（P〉0.05）.The levels of IL-2 and IL-12p40 were obviously correlated with the levels of FT3 and FT4.Conclusions Factors IL-2 and IL-12p40 most probably take part in the development of Grave＇s disease.Moreover,the levels of these two factors are negatively correlated with the levels FT3 and FT4.

关 键 词：GRAVE病 白细胞介素-2 白细胞介素-12p40 自身免疫 

分 类 号：R581.1[医药卫生—内分泌] R817.5[医药卫生—内科学]