女性更年期咽异感症的病因学探讨  

Research of Pharyngeal Paraesthesia in Female Climacterium

作　　者：柳庆君[1] 尹建平 张玲燕[1] 罗刚[1] 邓伟[1] 胥斌[1] 

机构地区：[1]绵阳市中心医院耳鼻咽喉科,四川绵阳621000

出　　处：《华西医学》2012年第9期1346-1348,共3页West China Medical Journal

基　　金：四川省科技厅科技支撑项目(09-06-0701077)~~

摘　　要：目的进一步探讨更年期咽异感症的发病机制,为正确的诊治该疾病提供新的思考。方法试验组纳入2011年1月-2012年2月女性更年期咽异感症患者24例,年龄41～51岁;对照组纳入咽痛为主要表现的急慢性咽炎患者24例,年龄18～44岁。运用低浓度丁卡因溶液及氯霉素溶液喷雾咽腔,观察更年期咽异感症患者与急慢性咽炎患者用药后的治疗反应。结果更年期咽异感症患者使用丁卡因后,咽部异物感症状普遍加重,而急慢性咽炎患者咽痛症状则有减轻,组间构成比差异具有统计学意义(χ2=25.552,P<0.05);氯霉素溶液喷雾后,两组患者差异无统计学意义(χ2=0.520,P>0.05)。结论局部炎症并非更年期咽异感症的真实原因,更年期感觉神经功能的快速退行性变所引起的感觉不适应,即咽部感觉神经功能的下降,可能是咽异感症的最本质原因,针对神经功能退行性变的处理,才是更年期咽异感症的最佳治疗方案。Objective To explore the nosogenesis of pharyngeal paraesthesia in female climacterium.Methods Between January 2011 and February 2012,24 female climacterium patients with pharyngeal paraesthesia（41-51 years old） and 24 female patients with acute or chronic pharyngitis（18-44 years old） were divided into the pharyngeal paraesthesia and control group,respectively.Low concentration of tetracaine hydrochloride solution and chloramphenicol solution were used at the pharyngeal of both groups,and the therapeutic effect was observed.Results Five minutes after sprayed with low concentration tetracaine hydrochloride solution,the patients in the pharyngeal paraesthesia group got worse but the symptoms of the patients in the control groupwere alleviated;the difference between the two groups was significant（χ^2=25.552,P〈0.05）.The difference between the two groups after chloramphenicol spraying was not significant（χ^2=0.520,P〈0.05）.Conclusions Pharygeal inflammatory response is not the true reason of pharyngeal paraesthesia in female climacterium.The fast development of hypesthesia in this period may be the true reason.Dealing with hypesthesia should be the best treatment.

关 键 词：更年期 咽异感症 病因学 

分 类 号：R766[医药卫生—耳鼻咽喉科]