围生因素与足月儿高间接胆红素血症巢式病例对照研究  

Nested Case-control Study of the Relationship between Perinatal Factors and Unconjugated Hyperbilirubinemia in Full-term Neonates

作　　者：彭好[1] 蒲友华[1] 胡波[1] 刘定远[1] 袁涛[1] 

机构地区：[1]遂宁市中心医院儿科,四川遂宁629000

出　　处：《华西医学》2012年第9期1369-1371,共3页West China Medical Journal

摘　　要：目的探讨围产期各种相关因素与高间接胆红素血症发病的关系。方法选择2011年1月-5月85例产科出生足月高间接胆红素血症患儿血清总胆红素升高(依据其小时龄)达到全国新生儿学组干预推荐方案光疗标准、且结合胆红素<34μmol/L,即高间接胆红素血症。同时按同性别同年龄阶段出生抽取85例无高胆红素血症足月儿按1︰1配对作对照组。采用单因素分析和条件logistic回归分析的方法,筛选高间接胆红素血症发病的危险因素。结果引起高间接胆红素血症的围生因素包括胎龄、产式、窒息、开奶时间延迟、胎粪排出时间延迟、喂养方式、出血、低血糖、红细胞比容和出生体质量下降。其中引起高间接胆红素血症独立的高危围生因素为胎龄、开奶时间延迟、低血糖、出血、红细胞增多症和出生体质量下降。结论临床对具有多种高危围生因素的患儿应提高对其发生高胆红素血症可能的预见性,及早采取预防措施。Objective To explore the correlation between perinatal factors and unconjugated hyperbilirubinemia in full-term neonates.Methods Between January and May 2011,85 neonates with unconjugated hyperbilirubinemia were selected and 85 full-term infants without hyperbilirubinemia were also selected at the same period as the control group.A total of 17 risk factors were listed and analyzed by the methods of single-factor analysis and logistic regression analysis Results After single-factor analysis,there were significant differences of 10 perinatal factors in two groups,including gestational age,labor ways,feeding ways,delayed feeding,internal hemorrhage,hypoglycemia,polycythemia,body weight loss,asphaxia,and delayed passage of meconium.The gestational age,delayed feeding,internal hemorrhage,hypoglycemia,polycythemia,and body weight loss were the main risk factors.Conclusion We should improve the predictability of possibility of risk factors of neonatal unconjugated hyperbilirubinemia and take preventive measure at early stage.

关 键 词：新生儿 高间接胆红素血症 围生因素 

分 类 号：R722.17[医药卫生—儿科]