Linking innate and adaptive immunity  

作　　者：SHI Yi GAO George Fu 

机构地区：[1]CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology,Chinese Academy of Sciences,Beijing 100101,China [2]Research Network of Immunity and Health(RNIH),Beijing Institutes of Life Science,Chinese Academy of Sciences,Beijing 100101,China

出　　处：《Chinese Science Bulletin》2012年第31期4100-4102,共3页

摘　　要：The evolution of mechanisms to fight pathogens in plants and animals is reflected in the complexity of the components of their so-called immune systems. Higher vertebrates haveThe evolution of mechanisms to fight pathogens in plants and animals is reflected in the complexity of the compo- nents of their so-called immune systems. Higher vertebrates have evolved two different ways to protect themselves against infectious pathogens [1]. The first is termed innate immunity and is mediated by non-clonatly distributed re- ceptors, which can also be found in plants with less com- plexity, while the second is termed adaptive immunity using clonally distributed receptors. It is thought that adaptive immunity is evolutionarily conserved and is present in or- ganisms from early evolutionary periods, such as the am- phioxus [2-4]. Because of the diversity of clonally distrib- uted receptors, including T cell receptors and immunoglob- ulins, the adaptive immune system is capable of the precise recognition of almost all biological structures. In contrast, the innate immune system is mediated by pattern recogni- tion receptors, such as Toll-like receptors （TLR）,

关 键 词：先天免疫 适应性 TOLL样受体 受体介导 动物病原体 连接 免疫系统 动物进化 

分 类 号：R392.1[医药卫生—免疫学]