糖尿病性心肌病变患者胰岛素强化治疗前后氧化应激水平的变化  

Effect of continuous subcutaneous insulin injection on oxidative stress level in patients with diabetic cardiomyopathy

作　　者：黄海[1] 宋成运[1] 杜大勇[1] 马建新[1] 李运田[1] 张世俊[1] 许玉韵[2] 

机构地区：[1]解放军第305医院心脏病中心,北京100017 [2]北京大学第一医院心内科,北京100034

出　　处：《心脏杂志》2012年第5期606-608,共3页Chinese Heart Journal

摘　　要：目的:评价糖尿病性心肌病(DCM)患者胰岛素泵强化治疗前后氧化应激水平的变化。方法:30例DCM患者采用胰岛素泵强化治疗,治疗达标前后进行超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)、丙二醛(MDA)水平测定并进行比较。结果:胰岛素泵强化治疗后,患者血浆中的SOD、GSH-PX水平明显上升(P<0.01)、MDA水平明显下降(P<0.01)。空腹血糖、餐后2 h血糖、胰岛素抵抗指数、总胆固醇、三酰甘油、低密度脂蛋白、游离脂肪酸明显降低(P<0.05),胰岛素分泌功能指数明显上升(P<0.05)。结论:DCM患者使用胰岛素泵强化治疗后氧化应激水平明显降低。AIM： To evaluate the effect of continuous subcutaneous insulin injection on oxidative stress level in patients with diabetic cardiomyopathy （DCM）. METHODS： Thirty patients with DCM Were treated with continuous subcutaneous insulin injection. SOD, CSH-PX and MDA were compared before and after insulin pump therapy. RESULTS： After treatment, SOD and GSH-PX levels significantly increased, whereas the MDA level significantly decreased （ P 〈 0. 01 ）. CONCLUSION ： Oxidative stress level in DCM patients significantly decreases after continuous subcutaneous insulin injection treatment.

关 键 词：心肌病 糖尿病性 胰岛素泵 氧化应激 

分 类 号：R542.2[医药卫生—心血管疾病]