红霉素联合β-内酰胺类抗菌药物治疗婴幼儿支气管肺炎的临床观察  

Efficacy of Erythromycin Combined with β-lactams for Infant Bronchopneumonia

作　　者：彭小华[1] 王莉[1] 宫奇莲[1] 杨旭荣[1] 

机构地区：[1]山西省长治市妇幼保健院儿内科,山西长治046000

出　　处：《中国医院用药评价与分析》2012年第8期719-721,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:探讨婴幼儿支气管肺炎的抗菌药物经验性治疗,观察红霉素联合β-内酰胺类抗菌药物治疗婴幼儿支气管肺炎的疗效。方法:将108例支气管肺炎住院患儿以随机抽样法分为2组,对照组(n=54)给予头孢菌素类抗菌药物静脉滴注治疗,按常规给予止咳、化痰等药物治疗;治疗组(n=54)在此基础上联合应用红霉素20 mg.kg-1.d-1,连续治疗5～7 d。结果:治疗组总有效率为92.6%(50/54),对照组为83.3%(45/54),治疗组明显好于对照组(P<0.05);住院期间治疗组患儿平均住院时间、止咳时间、肺部啰音消失时间均比对照组明显缩短,2组比较差异有统计学意义(P<0.05);2组不良反应发生率均较低,且无显著差异(P>0.05)。结论:红霉素联合β-内酰胺类抗菌药物治疗婴幼儿支气管肺炎安全、有效,有助于缩短疗程。ABSTRACT OBJECTIVE：To explore the empiric antibiotic therapy efficacy of erythromycin combined with /3-1actams for infant for infant bronchopneumonia and to evaluate the bronchopneumonia. METHODS ： 108 infant bronchopneumonia cases were randomly assigned to receive either cephalosporins （iv gtt） alone （control group, n = 54） for routine cough-relieving and phlegm-dissipating or cephalosporins plus erythromycin （20 mg. kg ^- 1. d ^- 1 ） for 5- 7 consecutive days （treatment group, n = 54）. RESULTS： The total response rates in the treatment group and thecontrol group were 92. 6% （50/54） and 83.3% （45/54） , respectively （P 〈0. 05） ; the average hospital stay, time to cough stopping, time to extinction of tales in lungs were all significantly shorter in the treatment group than in the control group （ P 〈 0. 05 ） ; however, the adverse drug reactions in both groups were mild and no significant differences were noted between the two groups （ P 〉 0. 05 ）. CONCLUSIONS： Addition of erythromycin toβ-lactams antibiotics was proved to be safe and effective with shorter course of treatment needed for infantile bronchopneumonia.

关 键 词：支气管肺炎 红霉素 Β-内酰胺类抗菌药物 疗效 

分 类 号：R978.1[医药卫生—药品]