盐酸法舒地尔注射液与果糖注射液配伍的稳定性考察  

Compatible Stability of Mixture of Fasudil Hydrochloride Injection with Fructose Injection

作　　者：徐梅[1] 韩强[1] 

机构地区：[1]徐州医学院附属医院药剂科,江苏徐州221002

出　　处：《中国医院用药评价与分析》2012年第9期814-816,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:考察盐酸法舒地尔注射液在室温[(25±2)℃]下与果糖注射液配伍的稳定性。方法:模拟临床用药浓度将盐酸法舒地尔注射液加入果糖注射液中,混合均匀后,在室温[(25±2)℃]下观察并测定6 h内配伍液的外观和pH值变化,采用高效液相色谱法测定法舒地尔的含量,并考察是有无新物质生成。结果:在室温[(25±2)℃]条件下,0～6 h配伍液的外观、pH值、盐酸法舒地尔的含量均无明显变化。结论:盐酸法舒地尔注射液与果糖注射液配伍,在室温[(25±2)℃]下6 h内配伍液稳定。OBJECTIVE： To investigate the compatible stability of fasudil hydrochloride with fructose injection at room temperature [ （ 25 ± 2 ） ℃ ]. METHODS ： Fasudil hydrochloride at a simulated clinical concentration was added into in fructose injection, after thorough mixing, the appearance of the mixture was observed and its pH value was determined and the content of fasudil hydrochloride was determined by HPLC. Meanwhile, we also observed whether there was formation of new matter. RESULTS ： At room temperature [ （25 ± 2 ） ℃ ] , no marked change was noted for the mixture of fasudil hydrochloride with fructose injection within 0-6 hours after mixing with regard to its appearance, pH value and the content of fasudil hydrochloride. CONCLUSION ： At room temperature [ （25 ± 2） ℃ ], the mixture of fasudil hydrochloride injection with fructose injection was stable within 6 hours after mixing.

关 键 词：盐酸法舒地尔注射液 果糖注射液 配伍 稳定性 高效液相色谱法 

分 类 号：R969.2[医药卫生—药理学]