保心胶囊对大鼠急性心肌缺血模型心电图及瘀血模型血液流变性的影响  

The effects of PaoXin-capsules on the electrocardiogram of acute myocardial ischemia model and on the hemorheololgy of blood stasis model of rat.

作　　者：黄河清[1] 吴伟康[1] 唐铁军[1] 陈建萍[1] 

机构地区：[1]中山医科大学中西医结合研究所

出　　处：《西藏医药》2000年第3期9-10,共2页Tibetan Medicine

摘　　要：观察四逆汤制剂———保心胶囊抗心肌缺血的药理效应。方法 :运用垂体后叶素造大鼠急性心肌缺血模型 ,运用皮下注射大剂量肾上腺素加冰水冷浴造大鼠瘀血模型 ,观察保心胶囊对大鼠急性心肌缺血模型心电图ST段和瘀血模型血液流变性等指标的影响。结果 :保心胶囊低、高二个剂量组与模型组相比 ,可显著改善缺血心电图ST段和低切变率的全血粘度 (P <0 0 5)。结论 :保心胶囊可有效降低血液粘度 ,改善冠脉循环 ,保护缺血心肌。Object:To observe the pharmacological effects of PaoXin-capsules (which is a preparation of SiNi-decoction)on myocardial ischemia. Methods:Model of acute myocardial ischemia of rats was established by pituitrin,model of blood stasis of rats was established by high dose adrenaline subcutaneous injection and ice water socking.Using these models,we observed the effects of PaoXin-capsules on the electrocardiogram ST-section of acute myocardal ischemia model and the hemorheology of blood stasis model of rat. Results:compare with model groups,the ischemic electrocardiogram ST-section and the blood viscosity of low shear rate are improved obviously (P<0.05). conclusion:PaoXin-capsules can decrease viscosity of blood,improve circulation of coronary artery and protect ischemic myocardium.

关 键 词：急性心肌缺血 瘀血 心电图 血液流变性 

分 类 号：R285[医药卫生—中药学]