(±)-Sepicanin A的首次全合成  

Total Synthesis of (±)-Sepicanin A

作　　者：黄文倩[1] 杨金会[1] 郭冬冬[1] 落俊山[1] 

机构地区：[1]宁夏大学天然气转化国家重点实验室培育基地,宁夏银川750021

出　　处：《宁夏大学学报（自然科学版）》2012年第3期270-273,共4页Journal of Ningxia University(Natural Science Edition)

基　　金：国家自然科学基金资助项目(20962016;21162021);教育部"新世纪优秀人才支持计划资助"基金资助项目(NCET-09-0860);宁夏自然科学基金资助项目(NZ1006)

摘　　要：以2,4,6-三羟基苯乙酮和2,4-二羟基苯甲醛为原料,经4步以总收率16%得到最终产物——香叶基黄烷酮(±)Sepicanin A.合成的关键步骤是质子酸催化查尔酮形成苯并吡喃酮的同时脱去羟基保护基,一步得到目标产物(±)Sepicanin A.所有新化合物的结构都经过1 H-NMR,IR,MS分析表征.A facile approach for the first total synthesis of naturally occurring geranylated flavanoids sepicanin A has been obtained with total yield 16% starting from 2,4,6-trihydroxyacetophenone after four steps. The key step was the protic acids（HC1 or p-TsOH）-catalyzed benzopyrone formation in a protic polar solvent by deprotection and cyclization of chalcone in one step. All structures of new compounds were confirmed by IR,1H NMR and MS.

关 键 词：(±)-Sepicanin A 黄烷酮 香叶基黄烷酮 全合成 

分 类 号：O625.1[理学—有机化学]