白三烯受体拮抗剂联合激素治疗小儿中重度哮喘的临床研究  

The clinical study of leukotriene receptor antagonists combined with hormone in the treatment of children with moderate and severe asthma

作　　者：池晓群[1] 

机构地区：[1]广东省梅州市人民医院,广东梅州514031

出　　处：《吉林医学》2012年第27期5873-5874,共2页Jilin Medical Journal

摘　　要：目的:探讨白三烯受体拮抗剂联合激素在小儿中重度哮喘中的治疗效果。方法:选取94例中重度哮喘患儿为研究对象。将其随机分为均等的两组。其中对照组行常规激素治疗,试验组在对照组的基础上口服白三烯受体拮抗剂孟鲁司特。结果:治疗1周后对照组总有效率为87.2%,试验组总有效率为97.8%。统计分析结果显示,两组患者临床治疗效果差异有统计学意义(P<0.05)。此外,与对照组相比,试验组患儿临床症状和体征消失时间明显缩短,肺功能改善情况良好(P<0.05)。结论:对于中重度哮喘患儿的治疗,白三烯受体拮抗剂联合激素能明显改善患者的肺功能,缩短病程,提高疾病的治疗效果。Objective To investigate the treatment effect of leukotriene receptor antagonists combined with hormone in the treatment of children with moderate and severe asthma.Methods 94 cases of moderate and severe asthma in children for diagnosis and treatment were chosen as the research object.They were randomly divided into two equal groups.The control group was taken with conventional hormone therapy, and the experiment group was taken with oral leukotriene receptor antagonist montelukast on the basis of the control group.Results The total effective rate for the control group after treatment 1 w was 87.2%,and the total effective rate of the experimental group was 97.8%.The statistical analysis showed there was a statistically significant difference for the clinical outcomes of two groups of patients（P 〈 0.05）,In addition,compared with the control group,clinical symptoms and signs in the experimental group disappeared significantly shorter, and lung function improved in a good condition（P 〈 0.05）.Conclusion For the treatment of children with moderate and severe asthma,leukotriene receptor antagonists combined hormone can significantly improve patients＇ lung function,and shorten the course to improve the treatment effect of diseases.

关 键 词：白三烯受体拮抗剂 激素 儿童哮喘 

分 类 号：R725.6[医药卫生—儿科]