工业脂肪酶拆分烯丙酮醇  

Enzymic Resolution of (±)Allethrone in Industrial Lipase

作　　者：郭成[1] 曹飞[1] 韦萍[1] 欧阳平凯[1] 

机构地区：[1]南京化工大学制药与生命科学学院,江苏南京210009

出　　处：《精细化工》2000年第7期396-397,共2页Fine Chemicals

摘　　要：研究了工业脂肪酶拆分消旋体烯丙酮醇。采用龙马脂肪酶不对称水解烯丙酮醇乙酸酯 ,反应 72h后中止反应 ,经硅胶柱层析进行醇、酯分离 ,得到S 烯丙酮醇乙酸酯的过量对映值ee=87%,收率 68%;R 烯丙酮醇的过量对映值ee=73%,收率 52 %。Enzymic resolution of allethrone in industrial lipase was studied.The result showed that the racemic acetyl allethrone was hydrolysed asymmetricly by Long Ma lipase after 72 h.The enantiomeric excess of S acetyl allethrone was greater than 87%,the yield of it was 68% The enantiomeric excess of R allethrone was greater than 73%,the yield of it was 52%.

关 键 词：工业脂肪酶 烯丙酮醇 拆分 消旋体 

分 类 号：TQ224.7[化学工程—有机化工]