奥曲肽在大范围肝切除术后应用的临床研究  

Effects of octreotide on prevention of complications in patients after major hepatectomy

作　　者：肖华[1] 梅斌[1] 魏刚[1] 王睿[1] 许达峰[1] 张必翔[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院肝脏外科中心,武汉430030

出　　处：《临床外科杂志》2012年第9期632-634,共3页Journal of Clinical Surgery

摘　　要：目的 探讨使用奥曲肽降低大范围肝切除术后并发症的效果.方法 将120例实施大范围肝切除术的患者随机分为两组,试验组60例术后2h开始以25μg/h匀速静脉泵入奥曲肽,连用72h;对照组60例术后不使用生长抑素类药物.比较两组术后肝功能恢复情况、腹腔引流量、并发症的发生率等.结果 两组基本资料及术中参数等均具有可比性,无一例围手术期死亡,试验组术后平均腹腔引流量明显低于对照组,并发症的发生率低于对照组（18.3% vs 35%,P=0.04）,住院时间也明显缩短（11.8d vs 13.1d,P=0.04）,术后肝功能的恢复差异无统计学意义.结论 大范围肝切除术后早期、短程使用奥曲肽能够降低并发症的发生率,减少腹腔引流量,并不延缓肝功能的恢复.Objective To evaluate the effects of octreotide on prevention of complications in pa- tients who have received major hepatectomy. Methods One hundred and twenty patients who underwent major hepatectomy were randomly divided into study group and control group ,Two hours after the surgery, 60 patients in the study group received treatments with octreotide infusion of 25 μg/h for 72 hours, and the other 60 patients in the control group received same treatments except for octreotide. Postoperative abdomi-nal drainage, complications and liver function were compared between the two groups. Results The base-line characteristics and intraoperative parameters were similar between the two groups. There was none of perioperative death,and the average abdominal drainage volume in the study group was significantly less than that in the control group. There was a lower complication rate（ 18.3% vs 35%, P = 0.04） and a shorter postoperative hospital stay （ 11.8 d vs 13.1 d, P = 0.04 ） in the study group. There was no signifi-cant difference in liver function between the two groups. Conclusion Early and short-term use of octreoti-de could reduce abdominal drainage volume and complication rate after major hepatectomy, and it would not delay the recovery of liver function.

关 键 词：奥曲肽 大范围肝切除 并发症 

分 类 号：R657[医药卫生—外科学]