2008-2011年湖北省宜昌市手足口病的流行特征分析  

Etiology of hand,foot and mouth disease in Yichang,Hubei,2008-2011

作　　者：余云芳[1] 张谨 孙凤英[1] 苗云萌[3] 吴谨呈[1] 涂玉梅[1] 马静[1] 余枫华[1] 阮刚[1] 

机构地区：[1]宜昌市疾病预防控制中心病原微生物检验所,湖北宜昌443000 [2]宜昌市第三人民医院急诊科 [3]华中科技大学同济医学院

出　　处：《疾病监测》2012年第9期680-682,共3页Disease Surveillance

摘　　要：目的了解湖北省宜昌市手足口病的流行特征,为手足口病的综合防治提供科学依据。方法收集2008-2011年宜昌市包括各县(市、区)报告的手足口病疫情病例和聚集性病例的相关标本,采用荧光定量RT-PCR方法进行检测。结果在473份标本中,男女性别比为1.26∶1,手足口病发病高峰在春末和夏初;疱疹液的阳性检出率高于咽拭子(χ2=8.026,P<0.01)和口漱液(χ2=12.67,P<0.01);共检测到肠道通用病毒阳性标本298份,总检出率为73%,其中肠道病毒71型(EV71)阳性标本191份,柯萨奇病毒A组16型(Cox A16)阳性标本78份,其他肠道病毒为29份,EV71的检出率高于Cox A16(χ2=86.517,P<0.01)和其他肠道病毒(χ2=189.089,P<0.01)。结论宜昌市手足口病的病原体主要是EV71(64.1%)和Cox A16(26.2%),随不同年份优势毒株稍有差异,EV71是引起宜昌市2008-2011年手足口病病例的主要优势毒株类型。Objective To investigate the etiological characteristics of hand,foot and mouth disease（H FMD） in Yichang and provide evidence for the prevention and control of HFMD.Methods Real-time quantitative RT-PCR was conducted to detect the clinical samples collected from reported cases of HFMD in Yichang during 2008-2011.ResultsThe clinical samples were collected from 473 patients（the male and female ratio of the patients： 1.26： 1）.The incidence peak of HFMD was in late spring and early summer.The positive detection rate of herpes liquid was higher than those of throat swabs（χ2=8.026,P0.01） and mouth washing water（χ2=12.67,P0.01）.Totally 298 strains of enteric virus were detected（73%）,including 191 EV71 strains,78 strains of Cox A16 and 29 strains of other enteric viruses.The detection rate of EV71 was higher than those of Cox A16（χ2=86.517,P0.01） and other enteric viruses（χ2=189.089,P0.01）.Conclusion The predominant pathogen of HFMD was EV71（64.1%）,followed by Cox A16（26.2%） in Yichang during 2008-2011.

关 键 词：手足口病 病原学 肠道病毒 荧光定量RT-PCR 

分 类 号：R725.1[医药卫生—儿科]