隔药灸对寒凝型原发性痛经的量效关系及对前列腺素的影响  

Research on Dose-effect Relationship of Herbs-partitioned Moxibustion for Cold Accumulation Syndrome of Dysmenorrhea and Its Influence on Prostaglandin

作　　者：朱英[1] 苗芙蕊[2] 陈日兰[2] 姬乐[2] 

机构地区：[1]广西中医药大学附属瑞康医院针灸科,广西南宁530011 [2]广西中医药大学附属瑞康医院,广西南宁530011

出　　处：《辽宁中医杂志》2012年第10期2038-2041,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：2011年广西自然科学基金项目(2011jjA40267);2009年广西中医学院重点课题(ZD2009009)

摘　　要：目的:观察隔药灸神阙穴治疗寒凝型中度原发性痛经的量效关系及其对前列腺素的影响。方法:将120例符合纳入标准的病例按随机数字分为4组:观察A组、B组、C组和西药组各30例,并设正常空白对照组30例。在治疗前及治疗3个疗程后,于月经来潮48h内采集静脉血检测PGF2α、PGE2。结果:观察A组总有效率为96.7%,观察B组总有效率为93.3%,观察C组总有效率为90.0%,西药组总有效率为76.7%;观察A组、观察B组、观察C组各组PGF2α及PGE2指标治疗前后进行比较、西药组PGE2指标治疗前后进行比较(P<0.01),有显著统计学意义;西药组PGF2α指标治疗前后进行比较(P<0.05),有统计学意义。观察A组与B组、观察B组与C组、观察C组与西药组治疗后PGF2α及PGE2指标进行比较(P<0.05),有统计学意义;观察A组与C组、观察A组与西药组、观察B组与西药组治疗后PGF2α及PGE2指标比较(P<0.01),有显著统计学意义。观察组、西药组治疗前血清PGF2α含量均明显高于正常组水平;治疗后各组血清PGF2α含量均明显降低,观察A组降低更加显著,且恢复至正常组水平。观察组、西药组治疗前血清PGE2含量均明显低于正常组水平;治疗后各组血清PGE2含量均明显升高,观察A组升高更加显著,且恢复至正常组水平。结论:隔药灸治疗寒凝型痛经的疗效优于口服药物,且大灸量的疗效优于小灸量,且方便、安全、无副作用。隔药灸治疗寒凝型痛经的疗效机制与调节PGF2α及PGE2有关,即可降低经期外周血PGF2α含量,升高PGE2含量。Objective：To observe the clinical efficacy of dose-effect relationship of herbs-partifioned moxibustion on Shenque （RN8） for cold accumulation syndrome of dysmenorrhea and its influence on PGF2α and PGE2. Methods：120 cases of moderate cold accumulation syndrome of primary dysmenorrhea were randomly divided into four groups according to the SPSS11.0 statistics software. Another 30 cases were the normal control group. Among them,the observation group A, B and C were treated by herbs- partitioned moxibustion on RN8 and the medicine group was treated by western medicine. Before treatment and after 3 courses, the patients should take the PGF2ot and PGE2 tests in 48 hours when the menstruation period. Results：Group A：the total effective rate was 96.7% ;group B：the total effective rate was 93.3% ;group C：the total effective rate was 90.0%. The medicine group：the to- tal effective rate was 76.7%. Compared with the PGF2α and PGE2 score before and after treatment of observation A,B and C groups （P 〈 0. 01 ）, there was remarkably statistical significance;compared with the PGF2α and PGE2 score before and after treat- ment of the control group（ P 〈 0. 05 ）, there was statistics significance. Compared with the PGF2α and PGE2 score after treatmentbetween observation A and B. groups, observation B and C groups, observation C and the medicine groups （P 〈 0. 05 ）, there was statistics significance;Compared the PGF2ct and PGE2 score after treatment between observation A and C groups, observation A and the medicine groups, observation B and the medicine groups （ P 〈 0. 01 ） , there was remarkably statistical significance. Conclu- sion ： The clinical efficacy of primary dysmenorrhea treated by herbs-partitioned moxibustion was better than western medicine and large quantity of moxibustion was better than the small one. And the method is convenient, secure, and without adverse reactions. The mechanism has relationship with regulating prostaglandin, which means reducing PGF2ct in peripher

关 键 词：痛经 针灸疗法 隔药灸 神阙 前列腺素 

分 类 号：R246.3[医药卫生—针灸推拿学]