巯基-烯/炔点击化学研究进展  

Progress in Thiol-Ene/Yne Click Chemistry

作　　者：刘清[1] 张秋禹[1] 陈少杰[1] 周健[1] 雷星锋[1] 

机构地区：[1]西北工业大学理学院应用化学系、教育部空间物理与化学重点实验室,西安710129

出　　处：《有机化学》2012年第10期1846-1863,共18页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.51173146/E030904);国家重点基础研究发展规划(973计划)(No.2010CB635111)资助项目~~

摘　　要：近年来,点击化学以其应用范围广、反应条件简单、速度快,产率高、环境友好、选择性强等诸多优点受到科学家的青睐,点击化学的概念对有机合成领域有很大的贡献,在药物开发和生物医用材料等诸多领域中,它已经成为目前最为有用和吸引人的合成理念之一.而巯基-烯/炔点击化学是近年来发展衍生出来的一类新型的点击化学,它以光引发自由基反应为催化介质,充分将光引发过程的优点和传统的点击反应的特点相结合,在特定的区域和官能团间反应,具有高度的选择性,成为合成材料的又一重要途径.本文着重就巯基-烯/炔点击化学在制备功能性聚合物微球、两亲性的嵌段聚合物、分子器件材料、高度支化聚合物等领域及化学修饰与改性方面进行了评述,并对点击化学在新领域中的应用及其发展方向进行了展望.Click chemistry has attracted great interests due to a wide variety of superior merits, including a wide range of applications, simplified experimental condition, rapid reaction speed, higher functional group conversion, environmental friendly and selectivity. And conception of click chemistry contributed to the synthetic chemistry apparently, in particular, with respect to pharmaceutical manufacture and biomedical materials, resulting in the most useful and promising synthetic method. Furthermore, thiol-ene/yne click chemistry, utilizing inclusion of visible light or UV light as catalytic medium, is a comparatively novel kind of click chemistry in comparison to several types of conventional reactions. In addition, the proper- ties of the creative reaction stems from the combination the photoinitiated chemical reaction with the forementioned traditional click chemistry, providing a flexible approach to occur reaction within the oriented region and functional group. This review highlights the recent research on the preparation of functional polymeric microsphere, amphipathic block well-defined poly- mer, materials employed in the molecular device, desired dendritic polymers and chemistry modification via thiol-ene/yne click chemistry. Moreover, the problems and solutions are given for the future development ofthiol-ene/yne click chemistry.

关 键 词：点击化学 巯基-烯/炔 功能性聚合物微球 两亲性的嵌段聚合物 分子器件材料 高度支化聚合物 化学修饰与改性 

分 类 号：O631.3[理学—高分子化学]