川黄柏、关黄柏的化学成分及药理活性研究进展  

Advances in study on chemical constituents and pharmacological activities of Phellodendron chinese Schineid.and Phellodendron amurese Rupr.

作　　者：张冠英[1] 董瑞娟[1] 廉莲[2] 

机构地区：[1]沈阳药科大学教育部基于靶点药物设计与研究重点实验室,辽宁沈阳110016 [2]辽宁科技学院生物医药与化学工程学院,辽宁本溪117004

出　　处：《沈阳药科大学学报》2012年第10期812-821,共10页Journal of Shenyang Pharmaceutical University

基　　金：辽宁省博士科研启动基金资助项目(20101049);辽宁省高等学校杰出青年学者成长计划资助项目(LJQ2011129)

摘　　要：目的对川黄柏、关黄柏两种药用黄柏在化学成分、药理活性、分析检测方法、临床应用等方面进行综述,对比二者异同。方法通过系统文献调研,以近年来的40余篇中外文献为依据进行归纳总结。结果川黄柏和关黄柏作为《中华人民共和国药典》收载的两种药用品种,产地不同,化学组成存在相似性,但成分含量差别较大,尤其是主要药效成分,药理活性也不尽相同。结论临床应用大都混用为主,未做具体区分,但鉴于二者在药效成分组成、含量上有差别,建议依据成分对症应用,同时对各自的化学及活性研究还需深入。Objective To review the studies on chemical constituents,pharmacological activity,analytical methods and clinical applications of P.chinese Schineid.（Chuan Huang Bai）and P.amurese Rupr.（Guan Huang Bai）.Methods Based on the information from literatures,the differences between them were reviewed.Results P.chinese Schineid.and P.amurese Rupr.are recorded in the Pharmacopoeia of China as two medicinal species.There are large similarities on the chemical components between them,but the contents were different greatly,especially for the pharmacological constituents.At same time,the active effects were also different.Conclusions P.chinese Schineid.and P.amurese Rupr.have not been distinguished in current clinical applications till now,while,according to their efficacy components and bioactivities,the further studies on these fields are needed to be carried out.

关 键 词：川黄柏 关黄柏 化学成分 药理作用 临床应用 

分 类 号：R28[医药卫生—中药学]