老年原发性高血压颈动脉硬化与内源性类洋地黄物质相关性研究  

Related research between carotid atherosclerosis in elderly essential hypertension and endogenous digitalis-like substance

作　　者：马孝湘[1] 郑书展[2] 刘玉萍[1] 

机构地区：[1]四川省人民医院,四川成都610072 [2]泸州医学院附属医院,四川泸州646000

出　　处：《四川医学》2012年第9期1542-1544,共3页Sichuan Medical Journal

摘　　要：目的观察老年原发性高血压(EH)患者颈动脉IMT值及斑块形成与血浆内源性类洋地黄物质(EDLS)浓度的变化,探讨颈动脉硬化和血浆EDLS浓度在老年EH中的变化及其相互关系。方法应用彩色多普勒超声检测150例老年EH患者和60例血压正常的老年健康者颈动脉IMT值及斑块检出率,同时测定血浆EDLS含量。结果①对照组、EH1级组、EH2级组、EH3级组的血浆EDLS含量呈逐渐增加,差异有统计学意义(P<0.05),IMT值或斑块检出率也均随血压的增高而逐渐增加,差异有统计学意义(P<0.05);②相关分析表明IMT值与血浆EDLS水平呈正相关(r=0.872,P<0.01)。结论老年EH患者存在颈动脉硬化和血浆EDLS水平升高,EDLS与颈动脉硬化发生发展有明显关系。Objective Objeetive observation of carotid atheroselerosis and plasma EDLS concentrations in the elderly EH changes in their mutual relations. Methods Color Doppler uhrasonography detected 150 eases of elderly patients with EH and 60 patients with normal blood pressure in elderly healthy value of carotid IMT and plaque detection rate, while the determination of plasma EDLS content. Results Controls EH1-level group, EH2-1evel group, EH3-1evel group of plasma EDLS content was grad- ually increased, the difference was statistically significant （P 〈0.05） , IMT value or plaque detection rates were gradually in- creased with the increase in blood pressure, The difference was statistically significant （ P 〈 0. 05 ） ; Correlation analysis showed that IMT values and plasma EDLS level was positively correlated （ r = 0. 872,P 〈 0.01 ） . Conclusion Elderly patients with eld- erly essential hypertension has carotid atheroselerosis and blood plasma EDLS level to elevate, EDLS has the obvious relation with the occurrence and the development of carotid atheroselerosis.

关 键 词：原发性高血压 颈动脉硬化 内源性类洋地黄物质 

分 类 号：R544.1[医药卫生—心血管疾病] R543.4[医药卫生—内科学]