微创血肿清除术对脑出血患者血清胶质纤维酸性蛋白及铁蛋白变化的影响  

Minimally invasive surgery patients with cerebral hemorrhage of hematoma clear serum glial fibers acid protein and iron protein change

作　　者：高改云[1] 侯冰洁 郭娜[1] 和杰[1] 王玉肖[1] 杨玉霞[1] 

机构地区：[1]保定市唐县人民医院神经内科检验科,河北保定072350

出　　处：《四川医学》2012年第9期1630-1632,共3页Sichuan Medical Journal

摘　　要：目的探讨微创血肿清除术对脑出血(ICH)患者血清胶质纤维酸性蛋白(GFAP)、铁蛋白(SF)变化的影响。方法共纳入60例ICH患者,采用随机数字法平均分为两组,A组给予微创血肿清除术治疗措施;B组给予非手术治疗措施,所有患者均于治疗前、治疗后1、3、7、14d空腹抽取静脉血检测血浆GFAP及SF蛋白水平。结果治疗前两组患者血浆GFAP及SF水平差异无统计学意义(P>0.05)。与治疗前相比,治疗后1、3、7d两组患者血浆GFAP及SF水平均明显增高,差异有统计学意义(P<0.05);治疗后14dA组(微创血肿清除术组)患者血浆GFAP及SF水平较治疗前明显降低,差异有统计意义(P<0.05),而B组(常规治疗组)患者的GFAP及SF水平仍高于治疗前,差异有统计意义(P<0.05)。治疗后1、3、7、14d,A组(微创血肿清除术组)患者的血浆GFAP及SF水平均明显低于B组(常规治疗组)患者,差异有统计意义(P<0.05)。结论与常规内科治疗相比,微创血肿清除术可以明显降低患者的血浆GFAP及SF水平,降低患者病死率,改善长期预后,且有利于患者早期神经功能的恢复,值得临床推广应用。Objective Minimally invasive surgery patients with cerebral hemorrhage of hematoma clear serum glial fibers acid protein and iron protein change. Methods Participants included 60 cases of patients with ICH, by means of random digital method average divided into two groups, group A minimally invasive surgical treatment to hematoma clear measures; Group B give nonoperative treatment measures, all patients were in before treatment, after treatment, the 1,3,7,14d hollow extraction venous blood test GFAP plasma protein levels and SF. Results Two groups of patients before treatment plasma GFAP and SF level differ- ences between was statistically significant （ P 〉 0. 05 ）. Compared with before treatment, after treatment, the 1,3,7d two groups of patients GFAP plasma and SF were significantly higher level, more statistically significant difference （ P 〈 0.05 ） ; After treatment, the 14 dA group （ minimally invasive hematoma was cleared of plasma GFAP patients and SF before treatment level is reduced sig- nificantly, and more statistically significant difference （P 〈0.05 ）, and group B （ conventional treatment group） of patients GFAP and SF is still higher than the level before treatment, the difference is statistically significant （ P 〈 0. 05）. After treatment, the 1 , 3,7,14d, group A （minimally invasiye hematoma was cleared of the patients GFAP and SF plasma levels were significantly lower than group B （ conventional treatment group） patients, differences between statistically significant （ P 〈 0. 05 ）. Conclusion Compared with conventional medical treatment, minimally invasive hematoma was clear can be cut down obviously patients GFAP plasma and SF level, reduce the patients mortality, improve the long-term prognosis, and beneficial to the recovery of the patients with early neural function, it is worth clinical application.

关 键 词：微创血肿清除术 脑出血 胶质纤维酸性蛋白 铁蛋白 

分 类 号：R651.1[医药卫生—外科学]