菝葜抗小鼠移植性肿瘤的实验研究  

Study on anti-tumor effects of Ethyl acetate extract of Smilax china L.

作　　者：王红英 黄燕芬[2] 

机构地区：[1]浙江省兰溪市人民医院,兰溪321100 [2]浙江中医药大学,杭州310053

出　　处：《海峡药学》2012年第9期23-25,共3页Strait Pharmaceutical Journal

摘　　要：目的研究菝葜乙酸乙酯提取物体内抗移植性肿瘤的作用及其对小鼠的免疫调节作用,为菝葜的临床应用提供理论依据。方法菝葜乙酸乙酯提取物灌饲接种过H22的荷瘤小鼠,并通过测定其抑瘤率、胸腺指数、脾指数及碳廓清指数(K值)和吞噬指数(a值)来进一步探讨其抗瘤活性和对机体的免疫调节作用。结果菝葜乙酸乙酯提取物具有抗移植性肿瘤H22的作用,抑瘤率达43.3%;同时对机体也有明显的提高免疫力作用。结论菝葜具有抗移植肿瘤的作用,并可提高荷瘤小鼠的机体免疫力。OBJECTIVE To observe the anti-tumor and immunological regulation activity of ethyl acetate extract of Smilax china L.,and provide basic theory for clinical application.METHODS H22 tumor bearing mice orally were given Ethyl acetate extract of Smilax china L.and the anti-tumor activity and immunological regulation activity were investigated by determined its tumor inhibiting rate,thymus index,spleen index,carbon particle index（K value）and phagocytic index（a value） of the mice.RESULTS Ethyl acetate extract of Smilax china L.can significantly inhibit H22 tumor cell grows,the inhibiting rate was 43.3%,and with great immunological enhancement activity as well.CONCLUSION Ethyl acetate extract of Smilax china L.has anti-tumor activity and can enhance H22 tumor bearing mice′s immunological.

关 键 词：菝葜乙酸乙酯提取物 抗肿瘤 免疫促进 

分 类 号：R282.71[医药卫生—中药学] R969[医药卫生—中医学]