GSTT1基因多态性与IgA肾病易感性的研究  

Study on the Relation Between Glutathion S-transferase-theta Polymorphism and Susceptibility of IgA Nephropathy

作　　者：高雅琼[1] 王彩丽[1] 秦文斌 高丽君 南蕾[1] 贾妮亚[1] 

机构地区：[1]包头医学院第一附属医院肾内科 [2]内蒙古基因诊断研究所

出　　处：《放射免疫学杂志》2012年第5期555-557,共3页Journal of Radioimmanology

摘　　要：目的:了解谷胱甘肽硫转移酶T1(glutathion S-transferase-theta)基因多态性与内蒙古包头地区汉族人群IgA肾病易感性的相关性。方法:利用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术检测。随机收集包头医学院第一附属医院肾内科IgA肾病患者110例为病例组,健康体检正常者113例作为对照组。结果:GSTT1基因缺失型频率在IgA肾病患者组中为49.1%(54/110);在正常人体检组中为53.1%(60/113),(χ2=1.527,P>0.05)。二者之间差异无统计学意义。结论:GSTT1基因多态性与内蒙古包头地区汉族人群IgA肾病发生无相关性。Objective To investigate the correlativit of glutathion S-transferase-theta T1 gene polymorphism played a role in susceptibility of IgA nephropathy in han population in Baotou region of inner mongolia.Methods The polymorphism of glutathione S-transferase-theta gene was studied with PCR-RFLP in 110 patients with IgA nephropathy and 113 normal persons served as controls.Results The missing genotypic frequencies of glutathion S-transferase-theta in IgA nephropathy was 49.1%（54/110）and the group of control was 53.1%（60/113）.Conclusion The gene polymorphism of glutathion S-transferase-theta is not associated with IgA nephropathy in han population in Baotou region of inner mongolia.

关 键 词：IGA肾病 谷胱甘肽硫转移酶 基因多态性 

分 类 号：R586[医药卫生—内分泌]