瑞芬太尼复合丙泊酚与氯胺酮复合丙泊酚在小儿纤维结肠镜检手术中的比较  

Clinical Observation on the Application of Combination of Propofol-Remifentanil and Ketamine for Colonoscopy in Children

作　　者：苗琼[1] 陈春艳[1] 黄磊[1] 李超[1] 

机构地区：[1]云南省昆明市儿童医院,云南昆明650034

出　　处：《儿科药学杂志》2012年第10期7-8,共2页Journal of Pediatric Pharmacy

摘　　要：目的:探讨瑞芬太尼复合丙泊酚与氯胺酮复合丙泊酚在小儿纤维结肠镜检手术的临床应用。方法:肠镜检查手术患儿100例,随机分为氯胺酮复合丙泊酚组(K组50例)和瑞芬太尼复合丙泊酚组(R组50例)。K组给予氯胺酮2 mg/kg和丙泊酚2 mg/kg,R组给予瑞芬太尼0.5μg/kg和丙泊酚2 mg/kg,面罩吸氧,术中有肢动追加丙泊酚1～2 mg/kg。观察患儿心率(HR)、呼吸频率(RR)、氧饱和度(SpO2)变化,观察术后苏醒时间、离院时间及不良反应的发生情况。结果:两组患儿HR、RR、SpO2比较差异无统计学意义(P>0.05);R组患儿术后意识恢复时间、离院时间短于K组,K组患儿苏醒期有12例出现精神症状,两组比较差异均有统计学意义(P<0.05)。结论:瑞芬太尼复合丙泊酚应用于小儿纤维结肠镜检手术效果优于氯胺酮复合丙泊酚,满足手术要求,无不良反应发生,安全可行。Objective： To evaluate efficacy and safety of combination of propofol-remifentanil and ketamine for colonoscopy in children. Methods： One hundred children for colonoseopy were equally randomized into two groups： group K （50 cases） were infused propofol 2 mg/kg and ketamine 2 mg/kg; group R （50 cases） were infused propofol 2 mg/kg and remifentanil 0.5 μg/kg. If body movement were appeared, children were infused supplemental propofol 1 -2 mg/kg. The heart rate, pulse oxygen saturation, respiratory frequency, recovery time, length of hospital stay and untoward reaction incidence were monitored throughout the study. Results ： In two groups, there were no statistic differences in heart rate, pulse oxygen saturation and respiratory frequency （ P 〉 0.05 ）. There were statistical significance in length of hospital stay and untoward reaction incidence （P〈0.05）. Conclusions： The combination of propofol with remifentanil for eolonoscopy in children can provide satisfactory anesthesia, without untoward reaction.

关 键 词：纤维结肠镜检 丙泊酚 瑞芬太尼 

分 类 号：R614[医药卫生—麻醉学]