超高场强磁共振扩散张量成像对脑白质疏松症的诊断价值  

Evaluation of uitra-high field MR diffusion tensor imaging in diagnosis of leukoaraiosis

作　　者：张晖[1] 王勇[2] 耿左军[2] 杨海庆[2] 宋鹏[2] 柳青[2] 张璟[1] 苗江永[3] 

机构地区：[1]河北省人民医院医学影像科,石家庄050051 [2]河北医科大学第二医院医学影像科 [3]河北医科大学第二医院神经内科

出　　处：《中华老年心脑血管病杂志》2012年第10期1028-1031,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：河北省医学科学研究重点青年课题计划项目(20100078)

摘　　要：目的探讨超高场强磁共振扩散张量成像(DTI)对老年脑白质疏松症(LA)的诊断价值。方法单纯老年LA患者68例,应用超高场强3.0T磁共振行常规MRI及DTI检查,根据脑室周围高信号(PVH)分型,分别于侧脑室前角、后角周围脑白质及半卵圆中心测量脑白质病灶的平均扩散系数(ADC)和部分各向异性分数(FA)值,并进行统计分析。结果 68例老年中,PVH 1型42例,2型18例,3型6例,4型2例。随着PVH分型级别越高,ADC值越高,FA值越低(P<0.05,P<0.01),PVH与ADC值呈正相关(r=0.7328,P<0.01),与FA值呈负相关(r=-0.5816,P<0.01)。LA病灶在侧脑室前角、后角周围白质区和半卵圆中心区的ADC值逐渐升高,FA值则逐渐降低,差异有统计学意义(P<0.05)。结论应用超高场强DTI技术,可在特定脑白质病变区域通过更为准确的量化指标辅助临床对老年LA进行定性及定量的诊断。Objective To study the role of 3.0T MR diffusion tensor imaging（DTI） in diagnosis of leukoaraiosis（LA）. Methods Sixty-eight LA patients underwent 3.0 T conventional MRI and DTI. Average diffusion coefficient（ADC） and fractional anisotropy（FA） values of LA lesions, measured at the anterior and posterior horns of lateral ventricle and at the half-oval center, were compared and analyzed. Results Of the 68 elderly LA patients, 42,18,6 and 2 were diagnosed with type 1 periventricular hyperintensity（PVH 1）,type 2 PVH（PVH 2）,type 3 PVH（PVH 3） and type 4 PVH （PVH 4）, respectively. The PVH was positively related with the ADC （r=0. 7328,P〈0.01）and negatively related with the FA values（r=-0. 5816,P〈0.01）. The ADC values were higher than the FA values measured at the anterior and posterior horn of lateral ven- tricle and at the half-oval center for the LA lesions（P〈0.05）. Conclusion Ultra-high field MR DTI,as a more accurate quantitative indication for specific LA lesions,can contribute to the quali- tative and quantitative diagnosis of LA in elderly subjects.

关 键 词：磁共振成像 弥散 脑白质疏松症 侧脑室 记忆障碍 早期诊断 

分 类 号：R445.2[医药卫生—影像医学与核医学]