内皮微颗粒与糖尿病患者内皮功能障碍关系的研究进展  

The correlation of endothelial microparticles and endothelial dysfunction in patients with diabetes mellitus

作　　者：夏金盈[1] 李莹[1] 

机构地区：[1]同济大学附属东方医院心内科,上海200120

出　　处：《中国糖尿病杂志》2012年第10期792-793,共2页Chinese Journal of Diabetes

基　　金：上海市科委公关项目(10411968000)

摘　　要：近年来糖尿病患者的数量急剧上升,其发生心血管疾病的概率是非糖尿病患者的2～3倍,其中内皮功能障碍被认为是糖尿病患者发生动脉粥样硬化(AS)血栓形成并发症的关键因素之一。内皮微颗粒是内皮细胞激活或损伤时产生的膜性小囊泡,具有促进粘附、扩大炎症反应和诱导新生血管增生等作用。近来的研究发现内皮微颗粒的水平在糖尿病患者中升高,在糖尿病合并肾血管病变或急性冠脉综合征时尤为显著。此外,对内皮微颗粒的表型研究提示糖尿病患者内皮损伤的机制可能与凋亡有关。内皮微颗粒的发现为研究糖尿病的发病机制开辟了新的研究平台,有望成为研究糖尿病的新的热点。Currently the number of patients with diabetes mellitus （DM） is increasing in the population. The risk of cardiovascular disease is increased by 2 - 3 times in patients with DM than in patients without DM. Endothelial cell （EC） dysfunction are thought to be a key factor involved in the pathogenesis of athero-thrombogenic diabetic complications. Endothelial microparticles （EMPs） is submicron membrane vesicles shed from plasma membrane in response to endothelial cell activation or injury and plays a major biological role in adhesion, inflammation and angiogenesis. Recent studies demonstrate that EMPs are elevated in diabetic patients, especially in those with renal vascular lesions or acute coronary syndrome. Further more, the studies on phenotype of EMPs indicate that endothelial apoptosis may be a mechanism involved in endothelial dysfunction in diabetic patients. Thus, elucidating their role and their mechanisms of formation will bring new insights into the understanding DNL

关 键 词：糖尿病 内皮微颗粒 内皮功能障碍 内皮细胞凋亡 

分 类 号：R587.1[医药卫生—内分泌]