黄杞叶中黄酮类化学成分的研究  

Flavanoids from the Leaves of Engelhardtia roxburghiana

作　　者：孙彤[1] 邓安珺[1] 李志宏[1] 秦海林[1] 

机构地区：[1]天然药物活性物质与功能国家重点实验室,中草药物质基础与资源利用教育部重点实验室,中国医学科学院-北京协和医学院药物研究所,北京100050

出　　处：《中国药学杂志》2012年第20期1617-1620,共4页Chinese Pharmaceutical Journal

基　　金：重大新药创制科技重大专项(2009ZX09308)

摘　　要：目的研究黄杞(Engelhardtia roxburghiana wall.)叶的化学成分。方法黄杞叶经溶剂提取和萃取粗分后,用硅胶柱色谱法分离单体成分,用1H-NMR,13C-NMR,MS等方法鉴定结构。结果从黄杞叶中分离并鉴定了13个化合物:花旗松素(1),5,7,4'-三羟基二氢黄酮(2),山柰酚(3),二氢山柰酚(4),槲皮素(5),异黄杞苷(6),黄杞苷(7),落新妇苷(8),异落新妇苷(9),山柰酚-3-O-α-L-鼠李糖苷(10),5,7-二羟基色原酮-3-O-α-L-吡喃鼠李糖苷(11),5-羟基-3,7,3',4'-四甲氧基黄酮(12),槲皮素-3-O-α-L-吡喃鼠李糖苷(13)。结论化合物2,4,9,11,12为首次从该植物中分离得到。OBJECTIVE To investigate the chemical constituents of the leaves of Engelhardtia roxburghiana. METHODS Af- ter the plant materials were extracted and fractionated with solvents, column chromatography was used to isolate and purify the compounds. The structures were elucidated on the basis of 1H-NMR, 13 C-NMR, MS analysis and comparison with the literature data. RESULTS Thirteen compounds were identified as following ： taxilfolin （ 1 ）, 5,7,4＇-trihydroxy flavanone （ 2 ）, kaempferol （ 3 ）, dihydrokaempferol （4）, quercetin （ 5 ）, isoengeletin （ 6 ）, engeletin （ 7 ）, astilbin （ 8 ） , isoastilbin （ 9 ）, kaempferol-3-O-a-L-rhamnoside （ 10 ）, eucryphin（ 11 ）, 5-hydroxy-3 ,7 ,3＇ ,4＇-tetramethoxyflavone（ 12）, quercetin-3-O-a-L-rhamnoside（13）. CONCLUSION Compounds2, 4, 9, 11 and 12 were identified from the title plant for the first time.

关 键 词：黄杞 化学成分 二氢黄酮 黄酮 5 7 4’-三羟基二氢黄酮 二氢山柰酚 异落新妇苷 

分 类 号：R284[医药卫生—中药学]