尿毒症桡动脉钙化与自体动静脉内瘘失功的关系  

作　　者：强燕娟 龚立峰[1] 

机构地区：[1]江苏大学附属武进医院肾内科,213002

出　　处：《当代医学》2012年第30期3-4,共2页Contemporary Medicine

基　　金：常州市武进科技局基金(WS2009006)

摘　　要：目的旨在探讨尿毒症桡动脉钙化与动静脉内瘘(AVF)失功的关系。方法 40例慢性肾脏病5期患者于行首次行动静脉内瘘术时取桡动脉的修剪为动脉标本,对入选患者进行跟踪调查2年以上,将AVF于2年内失功者(10例)编为失功组,将另30例AVF使用正常者编为正常组;用钙盐特异性染色法(von Kossa法)对动脉进行钙化染色;应用计算机病理图像分析系统(IPP6.0)对组织切片进行半定量化图像分析;采用SPSS19.0统计分析软件进行数据处理。结果正常组与失功组桡动脉的钙盐染色结果差异有统计学差异,而两组的其他临床指标差异无统计学差异。结论尿毒症桡动脉钙化是AVF失功的独立危险因素。Objective To study the association of vascular calcification of radial arteries in uremia patients and failure of arterio-venous fistulas（AVF）. Methods Radial arteries of 40 patients with stage 5 of chronic kidney disease were collected as specimens, which were trimmed off radial arteries during the first arterio-venous fistula operation. A follow-up investigation had been carried out on all the patients for more than two years. Those ten patients whose AVF failed within two years were classified as the failure group, and the other thirty patients as the normal group. Specimens of the arteries were examined histologically for calcification with von Kossa staining. The images of histological sections were semi-quantitatively analyzed by Image-Pro Plus 6.0. And then SPSS 19.0 was used to do statistical analysis. Results The results of Von Kossa staining showed statistical difference between the normal group and the failure group. But there was no significant statistical difference of the other clinic indexes between the two groups. Conclusion Vascular calcification of radial arteries is an independent risk factor for the failure of AVF.

关 键 词：尿毒症 血管钙化 动静脉内瘘 

分 类 号：R473.5[医药卫生—护理学]