耐甲氧西林金黄色葡萄球菌的临床调查与耐药性分析  

Clinical investigation of methicillin-resistant Staphylococcus aureusand drug resistance

作　　者：崔金国[1] 孙景生[1] 邹万芹[1] 

机构地区：[1]天津市宝坻区人民医院药剂科,天津301800

出　　处：《中华医院感染学杂志》2012年第20期4614-4615,共2页Chinese Journal of Nosocomiology

摘　　要：目的探讨耐甲氧西林金黄色葡萄球菌(MRSA)临床感染的特点及对抗菌药物的耐药性。方法对2009年1月-2011年6月医院临床送检各类标本中分离出的103株MRSA,按照标本种类、科室分布、药物耐药性等进行分析。结果医院感染MRSA较多科室为神经外科及ICU,分别占35.9%、20.4%;103株MRSA主要标本来源为痰液、伤口分泌物,分别占43.7%、22.3%;MRSA除对万古霉素敏感外,对大环内酯类、氨基糖苷类、喹诺酮类及磺胺类药物呈不同耐药性,对青霉素和苯唑西林的耐药性为100.0%。结论只有正确掌握MRSA感染的分布与特征、监测其耐药性,合理使用抗菌药物,才能有效控制MRSA感染及扩散。OBJECTIVE To explore the characteristics of clinical infections caused by methicillin-resistant Staphylococcus aureus（MRSA）.and drug resistance.METHODS From Jan 2009 to Jun 2011,the distribution of the specimens and the departments from which 103 strains of MRSA as well as the drug resistance was analyzed.RESULTS MRSA infection mainly distributed in neurosurgery department（35.9%） and ICU（20.4%）;totally the 103 strains of MRSA were mainly isolated from the sputum and the wound secretion,accounting for 43.7% and 22.3%;MRSA varied in drug resistance to macrolides,aminoglycosides,quinolones,and sulfonamides except vancomycin.CONCLUSION Only we grasp the distribution and the characteristics of MRSA infections,monitor its drug resistance and reasonably use antibiotics can we effectively control the MRSA infections and its spread.

关 键 词：耐甲氧西林金黄色葡萄球菌 感染 耐药性 

分 类 号：R378.11[医药卫生—病原生物学]