2011年美国内分泌医师学会肢端肥大症诊疗临床实践指南解读  

Interpretation of medical guidelines for clinical practice for the diagnosis and treatment of acromegaly-2011 update

作　　者：田丹[1] 岑晶[1] 顾锋[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院内分泌科卫生部内分泌重点实验室,北京100730

出　　处：《中国实用内科杂志》2012年第10期764-774,共11页Chinese Journal of Practical Internal Medicine

摘　　要：肢端肥大症是一种较为少见的内分泌疾病,以生长激素分泌过多伴多系统受累为特征。因其隐匿且非特异的临床表现,患者常常往返于多个科室而不被临床医师重视甚至误诊。多数患者在明确诊断时常表现为垂体大腺瘤,合并的心血管系统、呼吸系统等相关并发症严重影响患者的生活质量,使治疗难度增加同时病死率升高。目前许多研究关注于肢端肥大症的生化诊断和缓解标准以及个体化的治疗方案,而药物治疗尤其是药物联合手术治疗使部分难治性肢端肥大症患者获得了最大程度的生化缓解。临床上需要对该病引起重视,提高诊断与治疗水平。Acromegaly is a rarely encountered endocrine disease featured by growth hormone hypersecretion and muhisystem involvement. Subjects often had to resort to multiple departments and may even be misdiagnosed as a result of insidious onset and non-specific clinical manifestations. Pituitary macroadenoma has not been uncommon in patients with newly diag- nosed acromegaly. The cardiovascular and respiratory complications may lead to markedly reduced quality of life, rendering it difficult to cure and an increasing mortality rate. That most studies have addressed biochemical diagnostic criteria and individualized treatment protocol of acromegaly has resulted in an optimal amelioration in terms of biochemical parameters via the treatment using medications,particularly the combination with surgery. More attention should be attached to acromegaly leading to improved capacity of the diagnosis and treatment.

关 键 词：肢端肥大症 生化缓解 诊疗指南 

分 类 号：R584[医药卫生—内分泌]