一种芯片式血流变分析系统的初步研究  

The preliminary study of hemorheology analysis system on chip

作　　者：杨国清[1] 廖彦剑[1] 陈礼[1] 杨军[1] 罗洪艳[1] 郑小林[1] 

机构地区：[1]重庆大学生物工程学院"生物流变科学与技术"教育部重点实验室,重庆400044

出　　处：《激光杂志》2012年第5期41-42,共2页Laser Journal

基　　金：重庆市科委科技计划攻关重点项目(cstc2009ab5202);重庆大学高校基本科研业务费项目(CDJZR10230013)资助

摘　　要：血液流变性质具有重要的病理和生理意义。针对血液流变特性测量的便携化和自动化发展,本文提出了一种基于PDMS芯片的简化的血液流变性质检测方法,初步设计并制作出一种集压力检测系统,平层腔,图像测速系统于一体的双面沟道微流控PDMS芯片血液流变检测系统。本文工作主要包括:基于芯片流路流速和压力变化的流体粘度测量方法推导;利用显微图像配准操作的PDMS双面结构模塑成型工艺进行测量芯片的制作;结合双光路显微图像测量和简化压力驱动进行的系统构建等。最后将此芯片应用于血液流变性质实验进行系统的功能性验证。Rheology properties have important pathological and physiological significance. According to the portable measurement of blood rheolngical properties and automation development, this thesis conunitted to a rheolngy properties analysis method based on PDMS chip. Designed a PDMS micro - fluidie chip which is included of pressure measurement system, smooth layer cavity and image speed detection system. This research includes： the measuring method of the viscosity relate to flow velocity and pressure; invented a doable - channel of PDMS molding method and we designed a micro - fluidic chip measurement system included many subsystem. Finally,we have experiments; the result proves the possibility of proposed design.

关 键 词：血流变 微流控芯片 显微图像 

分 类 号：TN248.1[电子电信—物理电子学]