艾滋病合并马尔尼菲青霉菌感染19例临床研究  

Clinical research on 19 AIDS cases complicated with penicilliosis marneffei

作　　者：王文文[1] 潘明安[2] 

机构地区：[1]中山大学附属第三医院血液科(中山大学血液病研究所),广东广州510630 [2]中山大学附属第三医院呼吸内科(中山大学呼吸疾病研究所),广东广州510630

出　　处：《中国当代医药》2012年第28期19-20,共2页China Modern Medicine

摘　　要：目的探讨艾滋病合并马尔尼菲青霉菌感染的临床特点。方法查阅2003年1月～2011年12月本院确诊的19例艾滋病合并马尔尼菲青霉菌感染患者的临床表现和实验室检查结果。结果艾滋病合并马尔尼菲青霉菌感染呈多部位播散,临床表现以发热、贫血、消瘦、咳嗽、腹痛、腹泻、皮疹、浅表淋巴结肿大、肝脾肿大为主,外周血CD4+淋巴细胞计数多数降低,血培养、骨髓培养阳性率高。结论马尔尼菲青霉菌是艾滋病机会性感染的重要病原体之一,主要发生于免疫缺陷的患者,临床表现无特异性,确诊需多部位取材培养或活检。Objective To explore the clinical features of penicillium marneffei （PM） infection in AIDS patients. Methods Clinical feature and laboratory results of 19 AIDS cases complicated with penicilliosis marneffei （PM） admitted in our hospital from January 2003 and December 2011 were retrospectively analyzed. Results PM infection in AIDS patients mostly involved multiple organs with clinical manifestations including fever, anemia, weight loss, cough, abdominal pain, diarrhea, skin rashes, superficial lymphadenopathy and hepatosplenomegaly. Most patients had CIX~ lymphocyte counts in peripheral blood decreased, PM was isolated most frequently from blood and bone marrow cultures. Conclusion PM has become one of the primary pathogens causing opportunistic infections in AIDS patients, it mostly occurs in immunodeficiency patients. Clinical manifestations of PM are not specific, diagnosis relies on cultures from multiple specimens or the finding of the pathogenic fungus from the bioptic tissues.

关 键 词：艾滋病 马尔尼菲青霉菌 临床研究 感染 

分 类 号：R512.91[医药卫生—内科学]