硬膜外小剂量吗啡联合静脉地佐辛与舒芬太尼用于食管癌术后镇痛的疗效观察  

Clinical observation of low-dose epidural morphine combined with intravenous dezocine and sufentanil used in postoperative analgesia on patients with esophagus cancer

作　　者：上官明化[1] 谢爱军[1] 李育蓉[1] 魏秀吾[1] 

机构地区：[1]福建省三明市第二医院(福建医科大学临床教学基地)麻醉科,福建三明366000

出　　处：《中国当代医药》2012年第28期90-91,共2页China Modern Medicine

摘　　要：目的观察硬膜外小剂量吗啡联合静脉地佐辛与舒芬太尼用于食管癌患者术后镇痛的疗效并评价其安全性。方法将48例择期食管癌根治术患者随机分为对照组和观察组,每组24例。对照组采用硬膜外小剂量吗啡+静脉舒芬太尼的镇痛方案,观察组在对照组基础上静脉增用地佐辛。观察并记录两组患者的镇痛效果及不良反应发生情况。结果通过视觉模拟评分测定,两组患者术后均取得了较好的镇痛效果,术后12h时观察组VAS评分显著优于对照组(P<0.05),观察组的不良反应发生率明显少于对照组(P<0.05)。结论硬膜外应用小剂量吗啡联合静脉舒芬太尼及地佐辛的多模式术后镇痛方案在保证优良镇痛效果的同时,有效减少了不良反应的发生。Objective To observe and evaluate the effect of low-dose epidural morphine combined with intravenous dezoeine and sufentanil used in postoperative analgesia on patients with esophagus cancer. Methods Forty eight patients with esophagus cancer were averagely divided into observation group （24 cases） and control group （24 cases）. Control group was given low-dose epidural morphine combined with intravenous sufentanil, observation group was given dezocine on the basis of control group. The analgesia effect and adverse reaction of the two groups were observed and recorded. Results Both two groups got a good analgesia effect by VAS score. The VAS score of observation group was significantly better than that of control group （P 〈 0.05） at 12 hours postoperative. The adverse reaction of observation group was significantly less than that of control group （P 〈 0.05）. Conclusion A multi-mode postoperative analgesia of low-dose epidural morphine combined with intravenous dezocine and sufentanil used in postoperative analgesia on patients with esophagus cancer can effectively reduce the adverse reaction with a good analgesia effect.

关 键 词：食管癌 术后镇痛 吗啡 地佐辛 舒芬太尼 

分 类 号：R614[医药卫生—麻醉学]