股骨头缺血性坏死的细胞治疗  

Cell therapy for the osteonecrosis of the femoral head

作　　者：孙大铭[1] 张洪[1] 

机构地区：[1]解放军总医院第一附属医院骨科研究所,北京100048

出　　处：《中国骨与关节杂志》2012年第5期518-521,共4页Chinese Journal of Bone and Joint

摘　　要：股骨头缺血性坏死（osteonecrosisofthefemoralhead，ONFH）是骨科常见病，多发于青壮年，男性多见。常快速进展导致髋关节疼痛和功能丧失。ONFH的病理特征在临床上得到证实，但其发生的病理生理过程尚不清楚。不同病因引起的ONFH表现过程相似，局部缺血，骨细胞坏死，修复不良，软骨下骨小梁结构破坏，最终产生软骨塌陷和骨关节炎的发生。Osteonecrosis of the femoral head （ONFH） is a kind of common orthopedic disease, which often results in hip joint dysfunction in young patients. ONFH is a pathological process caused by avascular necrosis of the femoral head. Disruption of blood supply is commonly believed to the main cause of ONFH, and further leads to hip joint destruction. The etiology of the disease is not fully understood. The use of corticosteroids and alcohol abuse are the 2 most common risk factors. In general, various joint-preserving procedures are used for the treatment of early- stage ONFH, including core decompression, various types of osteotomies, and different methods of vascularized or nonvascularized bone grafts. All these methods have their own problems, none of which have been found to be universally successful, and long-term follow-up results are lacking. However, the patients with early-stage ONFH should try to avoid the need for total hip arthroplasty （THA）, because they are still young, and the long-term effects of THA are not satisfactory. With the development of stem cell research and regenerative medicine, it is believed that changes in stem cells probably are the onset of ONFH, and the possible therapy for ONFH based on cell therapy has great potential. Recent studies have shed some light on cell therapy for ONFH. In this review, the epidemiology and pathophysiology of ONFH are presented, and meanwhile basic research and clinical applications of cell therapy for ONFH are discussed.

关 键 词：股骨头缺血性坏死 细胞治疗 病理生理过程 ONFH 髋关节疼痛 骨小梁结构 功能丧失 病理特征 

分 类 号：R681.8[医药卫生—骨科学]