他克莫司血药浓度监测中质控分析评价  

Evaluation on the quality control analysis in tacrolimus blood concentration monitoring

作　　者：郝堂娜[1] 孙玲[1] 李镇[2] 张宁[1] 张策[1] 聂维廷[2] 

机构地区：[1]大连医科大学附属第二医院药剂科,大连116027 [2]大连医科大学药学院,大连116027

出　　处：《实用药物与临床》2012年第9期575-577,共3页Practical Pharmacy and Clinical Remedies

摘　　要：目的通过对他克莫司血药浓度监测过程中随行的质控结果进行回顾性分析,确保他克莫司血药浓度测定结果的准确性。方法采用酶联免疫法测定全血中他克莫司低、高质控样品浓度,并对测定结果进行回顾性分析。结果 2007年6月-2010年7月进行他克莫司血药浓度监测的同时随行的质控样品测定结果均"在控",低浓度质控结果单因素方差分析测定数据之间差异有统计学意义(P<0.05),高浓度质控结果单因素方差分析测定数据间差异无统计学意义(P>0.05)。结论低、高质控监测结果均在误差允许范围内,表明他克莫司血药浓度监测结果准确度高,具有较好的临床指导意义。Objective To ensure the accuracy of tacrolimus blood concentration monitoring, a retrospective analysis of quality control in blood concentration monitoring was chose. Methods Whole blood concentrations of low and high control samples were determined by enzyme linked immunoassay and the results were analyzed retrospectively. Results In the period of June 2007 to July 2010, the quality control monitoring results of tacrolimus blood concen- tration were all in control. The low and high quality control results were analyzed respectively by one-way ANOVA, there were significant differences between low control samples （P 〈 0. 05 ）, but no difference between high control samples （ P 〉 0.05 ）. Conclusion The low and high quality control results were all in the range of allowable error,indicating that the results of tacrolimus blood concentration data were accurate and reliabile for clinical guide.

关 键 词：他克莫司 治疗药物监测 酶联免疫法 质控分析 

分 类 号：R96[医药卫生—药理学]