CD4^+CD25^+调节性T细胞与乙型肝炎病毒感染的研究进展  

CD4^+ CD25^+ regulatory T cells and hepatitis B virus infection

作　　者：庄勤建[1] 邱隆敏[1] 姚新生[1] 陈宇[1] 吕红[1] 

机构地区：[1]遵义医学院第一附属医院感染科,贵州省遵义市563000

出　　处：《世界华人消化杂志》2012年第24期2248-2253,共6页World Chinese Journal of Digestology

基　　金：教育部新世纪人才基金资助项目;No.NCET-10-0095;贵州省社会发展公关基金资助项目;No.黔科合SY[2010]3049~~

摘　　要：CD4+CD25+调节性T细胞(Tregulatory cells,Tregs)是近年来发现的一群具有免疫抑制功能的细胞亚群,其独特的作用方式及功能特征使其在自身免疫性疾病、移植免疫、肿瘤免疫和感染免疫中发挥着重要作用.近年的研究表明,Tregs细胞与乙型肝炎病毒(hepatitis B virus,HBV)感染后耐受、发病和转归相关.CD4＋ CD25＋ regulatory T cells are a recently discovered subset of CD4~ T cell populations that mediate immune suppression. Their unique mode of action and characteristics make them play an important role in autoimmune diseases, transplantation immunology, tumor immunity and anti-infection immunity. Recent studies sug- gest that regulatory T cells are closely associated with the pathogenesis and outcome of hepatitis B. Here we review recent advances in understand- ing the relationship between CD4~ CD25~ regu- latory T cells and hepatitis B virus infection.

关 键 词：乙型肝炎病毒 感染 调节性T细胞 细胞免疫 

分 类 号：R392[医药卫生—免疫学]