微卡(VACCAE)联合2H_3R_3Z_3E_3/4H_3R_3方案治疗初治涂阳肺结核的临床效果  

A clinical trial of Mycobaeterium Vaccae Vaccine combining 2H_3R_3Z_3E_3/4H_3R_3 in treating new pulmonary tuberculosis

作　　者：乐世峰[1] 程小星[2] 

机构地区：[1]浙江省慈溪市人民医院感染科,浙江慈溪315300 [2]解放军309医院结核病研究所,北京100091

出　　处：《中国现代医生》2012年第27期58-59,61,共3页China Modern Doctor

基　　金：国家自然科学基金(81071318)

摘　　要：目的应用微卡(VACCAE)联合常规抗结核药物2H3R3Z3E3/4H3R3治疗初治涂阳肺结核的临床疗效。方法选取100例初始涂阳肺结核患者,随机分为对照组50例和观察组50例,两组均采用"世界银行贷款+中国结核病控制项目"的2H3R3Z3E3/4H3R3方案治疗,观察组在上述常规化疗药基础上联用微卡22.50μg深部肌肉注射;观察两组的痰菌阴转率、病灶吸收率、空洞闭合率、临床症状改善情况、不良反应发生率。结果治疗1个月后,观察组临床症状完全消失率显著高于对照组(P<0.05)。观察组的痰菌转阴率、病灶吸收率、空洞闭合率均优于对照组(P<0.05)。微卡注射后无严重不良反应。结论微卡联合常规抗结核药物2H3R3Z3E3/4H3R3方案治疗初治涂阳肺结核能够快速缓解临床症状,且疗效显著不良反应小,具有临床应用价值。Objective To study the efficacy of Mycobacterium Vaccae Vaccine （VACCAE） combining 2H3R3Z3E3/4H3R3 in treating new smear positive tuberculosis（TB）. Methods One hundred new smear-positive TB patients were randomly divid- ed into treatment group and control group （each n = 50）. The treatment group received 2H3R3Z3E3/4H3R3 plus 22.50 txg VACCAE treatment for 6 months and the control group only received 2H3R3Z3E3/4H3R3 treatment for 6 months. The sputum conversion rate, the absorption rate of lung lesions, the rate of cavity closure, the improvement of clinical symptoms and the adverse reactions of mycobacterium vaccae were observed. Results One month after treatment, the rate of clinical symptoms completely disappearing in treatment group was significantly higher than those in control group （P 〈 0.05）. The sputum conversion rate, the absorption rate of lung lesions, the rate of cavity closure of treatment group were separately higher than the control group （P 〈 0.05）. No serious adverse reactions after injection of VACCAE were appeared. Conclusion VACCAE combined with conventional anti-TB drugs 2H3R3Z3E3/4H3R3 in treating new smear positive tuberculosis would have great clinical value which can quickly relieve clinical symptoms, got significant effects with no serious side effects.

关 键 词：微卡 常规抗结核药物 初治涂阳肺结核 

分 类 号：R521[医药卫生—内科学]