mTOR通路与Peutz-Jeghers综合征  

mTOR signaling pathway and Peutz-Jeghers syndrome

作　　者：陆相吉[1] 顾国利[2] 

机构地区：[1]武警内蒙古总队医院外一科,内蒙古自治区呼和浩特市010040 [2]中国人民解放军空军总医院普通外科,北京市100142

出　　处：《世界华人消化杂志》2012年第26期2443-2447,共5页World Chinese Journal of Digestology

基　　金：全军"十二五"后勤科研课题面上基金资助项目;No.CWS11J193;空军总医院临床攻关课题基金资助项目;No.KZG2009006~~

摘　　要：哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)所介导的细胞信号通路参与基因转录、蛋白翻译、核糖体合成、细胞凋亡等生物活动,是细胞内重要信号通路之一.其异常活化对某些遗传性疾病、肿瘤和糖尿病的发生关系密切.如何通过各种生物学手段影响该信号传导通路,从而对相关疾病的发生、治疗、转归、预后进行干预也成为现在研究的热点.本文结合近年来学者对mTOR信号通路的组成结构、功能及其在常染色体显性遗传病-Peutz-Jeghers综合征(Peutz-Jeghers syndrome,PJS)中作用的研究进展进行综述,以期能为以mTOR信号通路为靶点的分子靶向治疗应用于PJS的预防性治疗提供理论参考.The mammalian target of rapamycin （mTOR） signaling pathway is one of the most important intracellular signal transduction pathways and is involved in a series of biological activities, such as gene transcription, protein translation, ribosome synthesis, and cell apoptosis. The abnormal activation of the mTOR signaling pathway has a close relationship with the development of some hereditary diseases, tumors and diabetes. Intervention with biological processes of these diseases by influencing the mTOR signalling pathway with all kinds of biological means has become a hot area of research for several years. This article reviews the recent advances in understanding the composition and function of the mTOR signaling pathway and its role in the pathogenesis of Peutz-Jeghers syndrome. It is expected that molecular therapy targeting the mTOR signalling pathway can be used for preventive therapy of Peutz-Jeghers syndrome.

关 键 词：哺乳动物雷帕霉素靶蛋白 细胞信号通路 黑斑息肉病 靶向治疗 

分 类 号：R730.2[医药卫生—肿瘤]