大剂量沐舒坦持续泵入在肺癌合并慢性阻塞性肺疾病患者肺叶切除术术后的疗效观察  

Observation of curative effect on continuously-pumped large dose of Ambroxol in patients with lung cancer and COPD after pulmonary lobotomy

作　　者：唐明贵[1] 张军伟[1] 王红阳[1] 王宝华[1] 白静[1] 王印华[1] 

机构地区：[1]河北联合大学附属医院重症医学科,河北唐山063000

出　　处：《中国医药导报》2012年第27期86-87,共2页China Medical Herald

摘　　要：目的探讨大剂量沐舒坦在肺癌合并慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者行肺叶切除术后的疗效观察。方法将40例肺癌合并COPD行肺叶切除术后的患者随机分成两组,治疗组(n=20)持续静脉泵入大剂量沐舒坦(900 mg/d,连续7 d);对照组(n=20)持续静脉泵入常规剂量沐舒坦(90 mg/d,连续7 d),比较两组患者术后氧合指数、机械通气时间和发生肺不张、肺炎的差异。结果治疗组与对照组比较,术后7 d氧合指数差异有统计学意义(P<0.05);两组机械通气时间、肺不张发生率及肺炎发生率比较差异均无统计学意义(均P>0.05)。结论在肺癌合并COPD患者行肺叶切除术后应用大剂量沐舒坦能改善氧合,有可能缩短机械通气时间及降低肺不张、肺炎的发生率。Objective To investigate the application value of high dose of Ambroxol in patients with lung cancer and COPD after pulmonary lobotomy.Methods 40 cases of patients with lung cancer and COPD after pulmonary were randomly divided into two groups.The treatment group（n = 20） was given continuous intravenous infusion of high dose of Ambroxol（900 mg/d,for 7 days）,while the control group（n = 20） was given continuous intravenous infusion of conventional doses of Ambroxol（90 mg/d,for 7 days）.After 7 days of administration,oxygenation index,the time of mechanical ventilation,pulmonary atelectasis,pneumonia were compared between the two groups.Results Compared with the control group,the treatment group had significant difference in oxygenation index（P 0.05）.There were no significant differences in the time of mechanical ventilation,pulmonary atelectasis and pneumonia of the two groups（all P 0.05）.Conclusion The use of large dose of Ambroxol in patients with lung cancer and COPD after pulmonary lobotomy can improve the oxygenation index.Besides,it is possible to shorten the time of mechanical ventilation,reduce the rate of pulmonary atelectasis and pneumonia.

关 键 词：沐舒坦 慢性阻塞性肺疾病 肺癌 肺叶切除 

分 类 号：R563.1[医药卫生—呼吸系统]