细胞凋亡与慢性阻塞性肺疾病的相关性研究  

Correlation research of apoptosis and chronic obstructive pulmonary disease

作　　者：梁玉丽[1] 刘华[1] 

机构地区：[1]广东药学院附属第一医院,广东广州510080

出　　处：《中国当代医药》2012年第27期13-15,共3页China Modern Medicine

基　　金：广东省自然科学基金项目(S2011010002100)

摘　　要：慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)的发病率及死亡率都非常高,并且经济负担重,其发病机制至今仍未非常清楚。本文综述除慢性炎症、蛋白酶失衡、氧化与抗氧化失衡3种机制以外的近年来新发现的另一机制——细胞凋亡-抗凋亡失衡机制,这一机制在COPD患者慢性炎症细胞、肺内实质及间质细胞凋亡异常,以及与之前3种机制的相互联系。The morbidity and mortality of chronic obstructive pulmonary disease are very high, with heavy financial burden. Its pathogenesis is still not very clear. This article reviews a new discovery mechanism in recent years which except for chronic inflammation, protease imbalance and oxidation-antioxidant imbalance：cell apoptosis-antiapoptotic iantiapoptotic mbalance which is about the abnormal apoptosis of chronic inflammatory cells, parenchyma cells and interstitial cells of lung, and also review the relation of each other three mechanisms.

关 键 词：细胞凋亡 慢性阻塞性肺疾病 氧化与抗氧化失衡 蛋白酶失衡 

分 类 号：R562[医药卫生—呼吸系统]