良性前列腺增生与动脉粥样硬化相关指标的关系  

Correlation between benign prostate hyperplasia and the related indicators of atherosclerosis

作　　者：张瑞华[1] 秦明照[1] 

机构地区：[1]首都医科大学附属北京同仁医院干部医疗科,100730

出　　处：《中华老年医学杂志》2012年第10期847-849,共3页Chinese Journal of Geriatrics

摘　　要：目的探讨良性前列腺增生（BPH）与动脉粥样硬化相关指标的关系及其可能的机制。方法回顾性分析125例男性患者的年龄、身高、体质量、体质指数（BMI）、血清三酰甘油（TG）、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、糖化血红蛋白、前列腺特异性抗原（PSA），计算胰岛素抵抗指数（HOMA—IR），测定前列腺体积（PV），并获取双侧的踝臂指数（ABI）及心踝血管指数（CAVI）指标。按照PV分为BPH组75例及非BPH组50例，并进行PV与上述危险因素相关性分析。结果BPH组BMI、TG、PSA、HOMA—IR、右CAVI均高于非BPH组，右-ABI低于非BPH组（F2．177，2．033，3．060，2．859，3．085，2．557，均P〈O．05）。BPH组糖尿病及冠心病的发生率分别为52％、36％，高于非BPH组30％、10％（χ2值-5．917，10．648，P值=0．015、0．001）。Pearson相关分析显示PV与BMI、TG、PSA、右CAVI、左-CAVI呈正相关（r=0．336、0．216、0．556、0．295、0．389，均P〈0．05）。结论胰岛素抵抗、BPH和动脉粥样硬化之间可能存在密切联系。动脉粥样硬化导致前列腺组织缺血缺氧是BPH的可能机制之一。Objective To investigate the correlation between benign prostate hyperplasia（BPH） and atherosclerotic related indicators. Methods Totally 125 patients were divided into two groups based on prostate volume（PV） ： 50 cases without BPH （PV≤30 ml） and 75 cases with BPH （PV〉30 ml）. Age, body mass index （BMI）, triglycerides （TG）, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, glyeosylated hemoglobin, prostate specific antigen （PSA）, HOMA-IR, bilateral ankle brachial index （ABI） and cardio ankle vascular index （CAVI） were measured and calculated. All these indicators were compared between two groups. The correlations of these indicators with PV were analyzed. Results BMI, TG, PSA, HOMA-IR and righ〉CAVI in BPH group were higher than in group without BPH （t= 2. 177,2. 033,3. 060,2. 859, 3. 085, all P^0. 05） ,and right ABI was lower in the BPH group than in group without BPH （t= 2. 557,P〈0.05）. The incidences of diabetes and coronary diseases in BPH group were increased compared with those without BPH （52% and 36% vs. 30% and 10%, χ2=5.917,10.648, P= 0. 015,0. 001, respectively）. PV was positively correlated with BMI, TG, PSA, right-CAVI, left- CAVI（r=0. 336,0. 216,0. 556,0. 295,0. 389,ai1 P〈0.05）by Pearson analysis. Conclusions BPH is closely correlated with insulin resistance and atherosclerosis. Atherosclerosis might cause prostate chronic ischemia and hypoxia, which may play a role in the pathogenesis of BPH.

关 键 词：前列腺增生 动脉粥样硬化 

分 类 号：R697.3[医药卫生—泌尿科学] R543.5[医药卫生—外科学]